Management of Severe Fever with Thrombocytopenia Syndrome-Associated Encephalopathy with Mixed Pulmonary Mold Infections: A Case Report
| Author | Chenyi Wang | en |
| Author | Lian Tan | en |
| Author | Qi Zhang | en |
| Author | Yao Yuan | en |
| Author | Lishen Liu | en |
| Author | Zhengfeng Wen | en |
| Author | Yahong Qu | en |
| Author | Xiongxiong Wang | en |
| Author | Zhongliang Ye | en |
| Author | Shibo Li | en |
| Author | Dongjun Hu | en |
| Issued Date | 2025-11-30 | en |
| Abstract | Introduction: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease of global concern. This case report describes a patient with SFTS-associated encephalopathy complicated by mixed pulmonary infections with Aspergillus fumigatus and Rhizopus microsporus in Ningbo, China — a combination that has not been previously reported. Case Presentation: A forty-five-year-old man with confirmed severe fever with thrombocytopenia syndrome virus (SFTSV) infection developed pulmonary co-infection by Aspergillus and Rhizopus, complicated by massive hemoptysis. He received combined antifungal therapy with liposomal amphotericin B and isavuconazole, as well as bronchoscopy and bronchial artery embolization (BAE). Due to recurrent hemoptysis, a left lower lobectomy was performed, resulting in complete clinical and radiological recovery. Conclusions: This case highlights the importance of early recognition and dynamic reassessment of fungal infections in SFTS patients. Prompt initiation of broad-spectrum antifungal therapy and timely surgical intervention are key to improving survival. Nevertheless, as a single case, the findings should be interpreted cautiously; further studies are needed to determine whether similar dual fungal infections occur more widely in SFTS patients or under specific immunosuppressive conditions. | en |
| DOI | https://doi.org/10.5812/jjm-166706 | en |
| Keyword | Severe Fever with Thrombocytopenia Syndrome | en |
| Keyword | SFTS | en |
| Keyword | Mixed Mold Infection | en |
| Keyword | <i>Aspergillus</i> | en |
| Keyword | <i>Rhizopus microsporus</i> | en |
| Keyword | Liposomal Amphotericin B | en |
| Publisher | Brieflands | en |
| Title | Management of Severe Fever with Thrombocytopenia Syndrome-Associated Encephalopathy with Mixed Pulmonary Mold Infections: A Case Report | en |
| Type | Case Report | en |