Soluble T Cell Immunoglobulin and Mucin Domain-3 (sTIM-3) Predicts Graft-Versus-Host Disease (GVHD) in Iranian Allogeneic Hematopoietic Stem Cell Transplantation
| Author | Ronak Nalini | en |
| Author | Elham Roshandel | en |
| Author | Maria Tavakoli Ardakani | en |
| Author | Mohammad Hossein Kazemi | en |
| Author | Haniyeh Ghaffari-Nazari | en |
| Author | Abbas Hajifathali | en |
| Author | Masoud Soleimani | en |
| Orcid | Ronak Nalini [0000-0002-2070-3681] | en |
| Orcid | Elham Roshandel [0000-0002-3698-4342] | en |
| Orcid | Maria Tavakoli Ardakani [0000-0002-9230-2318] | en |
| Orcid | Mohammad Hossein Kazemi [0000-0002-2899-9755] | en |
| Orcid | Haniyeh Ghaffari-Nazari [0000-0002-4129-6018] | en |
| Orcid | Abbas Hajifathali [0000-0002-2711-9277] | en |
| Orcid | Masoud Soleimani [0000-0003-1972-7771] | en |
| Issued Date | 2022-04-30 | en |
| Abstract | Background: T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune-checkpoint molecule that is upregulated following allogeneic immune responses and could play an important role in the development and pathogenesis of graft-versus-host disease (GVHD). The soluble form of TIM-3 (sTIM-3) is increased following the upregulation of membranous TIM-3. Objectives: The aim of this study was to evaluate the association between plasma level of sTIM-3 and acute GVHD (aGVHD) incidence in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: Blood samples were collected from 42 allo-HSCT patients and 20 healthy individuals 2 weeks after allo-HSCT. The plasma level of sTIM-3 was measured using enzyme-linked immunosorbent assay (ELISA). The clinical and demographic data of patients were collected from the clinical documents. Data analysis was evaluated using student t-test and one-way ANOVA tests. P-values less than 0.05 were assumed statistically significant. Results: Among 18 (42.8%) patients with aGVHD symptoms, 10 (23.8%) had severe GVHD and 8 (19%) experienced mild GVHD. Plasma sTIM-3 levels at day +14 were significantly higher in patients who developed aGVHD compared to allo-HSCT patients without GVHD and also the healthy control individuals (P-value = 0.015 and < 0.001). Among the aGVHD patients, the sTIM-3 levels in those with severe GVHD were approximately 2.5 times higher than those with mild GVHD (P-value < 0.001). Conclusions: We have identified a high plasma level of sTIM-3 as a valuable biomarker in predicting the development of acute GVHD, especially severe aGVHD in allo-HSCT patients. | en |
| DOI | https://doi.org/10.5812/ijcm-120888 | en |
| Keyword | Hematopoietic Stem Cell Transplantation | en |
| Keyword | Graft-Versus-Host Disease | en |
| Keyword | TIM-3 | en |
| Keyword | GVHD Biomarker | en |
| Publisher | Brieflands | en |
| Title | Soluble T Cell Immunoglobulin and Mucin Domain-3 (sTIM-3) Predicts Graft-Versus-Host Disease (GVHD) in Iranian Allogeneic Hematopoietic Stem Cell Transplantation | en |
| Type | Research Article | en |
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