Preparation of Ethyl Cellulose Microspheres for Sustained Release of Sodium Bicarbonate

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AuthorJia-Hui Wuen
AuthorXiao-Juan Wangen
AuthorShu-Juan Lien
AuthorXiao-Ying Yingen
AuthorJing-Bo Huen
AuthorXiao-Ling Xuen
AuthorXu-Qi Kangen
AuthorJian Youen
AuthorYong-Zhong Duen
Issued Date2019-04-30en
AbstractSustained release of thermal-instable and water-soluble drugs with low molecule weight is a challenge. In this study, sodium bicarbonate was encapsulated in ethyl cellulose microspheres by a novel solid-in-oil-in-oil (S/O/O) emulsification method using acetonitrile/soybean oil as new solvent pairs. Properties of the microspheres such as size, recovery rate, morphology, drug content, and drug release behavior were evaluated to investigate the suitable preparation techniques. In the case of that the ratio of the internal and external oil phase was 1: 9, Tween 80 as a stabilizer resulted in the highest drug content (2.68%) and a good spherical shape of microspheres. After the ratio increased to 1: 4, the microspheres using Tween 80 as the stabilizer also had high drug content (1.96%) and exhibited a sustained release behavior, with 70% of drug released within 12 h and a sustained release of more than 40 h. Otherwise, different emulsification temperatures at which acetonitrile was evaporated could influence the drug release behaviour of microspheres obtained. This novel method is a potential and effective method to achieve the encapsulation and the sustained release of thermal-instable and water-soluble drugs with low molecule weight.en
DOIhttps://doi.org/10.22037/ijpr.2019.1100651en
KeywordMicrospheresen
KeywordSodium bicarbonateen
KeywordStabilizeren
KeywordEncapsulationen
KeywordSustained releaseen
PublisherBrieflandsen
TitlePreparation of Ethyl Cellulose Microspheres for Sustained Release of Sodium Bicarbonateen
TypeOriginal Articleen

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Iranian Journal of Pharmaceutical Research