Intracerebroventricular Injection of Histamine Induces State-Dependency through H1 Receptors
| Author | Mohammad Reza Zarrindast | en |
| Author | Nazanin Malekmohamadi | en |
| Author | Soheila Fazli Tabaei | en |
| Author | Shamseddin Ahmadi | en |
| Issued Date | 2006-10-31 | en |
| Abstract | The aim of the present study was to investigate whether and by which mechanism; histamine can induce state-dependent retrieval of passive avoidance task. The pre-training or pre-test intracerebroventricular (i.c.v.) injection of histamine (20µg/mouse) impaired retrieval, when it was tested 24 h later. In the animals, which retrieval was impaired due to histamine pre-training administration, pre-test administration of histamine, with the same dose, restored retrieval. The H1 blocker, pyrilamine (20 µg/mouse, i.c.v.), but not the H2 blocker; ranitidine prevented the restoration of retrieval by pre-test histamine. A pre-test administration of histamine H3 receptor antagonist, clobenprobit, also reversed hitamine-induced impairment of memory retention. In conclusion, histamine can induce state-dependent retrieval through the H1 receptor H1 mechanism. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.686 | en |
| Keyword | Mouse | en |
| Keyword | State-dependent retrieval | en |
| Keyword | Memory | en |
| Keyword | Histamine receptor antagonist | en |
| Keyword | Histamine | en |
| Publisher | Brieflands | en |
| Title | Intracerebroventricular Injection of Histamine Induces State-Dependency through H1 Receptors | en |
| Type | Research Article | en |
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