Infectivity Period After Symptom Relief in SARS-CoV-2 Patients: An Experimental Trial
| Author | Aysan Vaez | en |
| Author | Amin Izadi | en |
| Author | Majid Mirmohammadkhani | en |
| Author | Mohammad Memarian | en |
| Author | Maral Hemati | en |
| Author | Parviz Kokhaei | en |
| Orcid | Aysan Vaez [0000-0002-5317-3250] | en |
| Orcid | Amin Izadi [0000-0001-9883-5708] | en |
| Orcid | Majid Mirmohammadkhani [0000-0001-6251-7484] | en |
| Orcid | Mohammad Memarian [0000-0003-4534-3018] | en |
| Orcid | Maral Hemati [0000-0003-3869-598X] | en |
| Orcid | Parviz Kokhaei [0000-0001-6544-4209] | en |
| Issued Date | 2022-01-31 | en |
| Abstract | Background: This study aimed to understand the infectivity period after symptom relief in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients using real-time reverse transcription polymerase chain reaction (RT-PCR). This would probably help prevent the disease spread by partially recovered patients to some extent. Methods: A total of 10 coronavirus disease 2019 (COVID-19) infected patients with mild to moderate illness, approved by RT-PCR, were followed daily. After 2 days of cessation of clinical symptoms, a nasopharyngeal and oropharyngeal sample RT-PCR was taken. If the patients’ test had a negative result, a repeated RT-PCR was performed 24 hours later. Moreover, if two consecutive tests had negative results, the patient was considered definitively treated, and the follow-up was terminated. However, if RT-PCR was positive, the test was performed 3 days later. The infectivity period after symptom relief and total infectivity period were calculated. The SARS-CoV-2 immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies were measured 1 month after symptom relief. The SPSS Software (version 20) was used for data analysis. Results: A total of 10 patients met the inclusion criteria to enter the study. There were 6 (60%) male and 4 (40%) female patients. The mean age of patients was 37.40 ± 7.975 years (minimum: 28 years, maximum: 51 years). The mean days passed from the onset of symptoms at the time of referring to Kowsar Hospital in Semnan, Iran, was 3.2 ± 0.919 days (minimum: 2 days, maximum: 5 days). The mean infectivity period after symptom relief was 6.9 ± 5.152 days indicating that it took about 7 days after symptom relief that the patients were considered completely treated according to RT-PCR results. However, the mean period of total infectivity was 16.6 ± 5.73 days. Moreover, 70% of patients had an IgM negative/IgG positive result 1 month after symptom relief; nevertheless, 30% of patients showed a delayed antibody response. Conclusions: The virus could be detected in nasopharyngeal and oropharyngeal samples in the studied patients up to 7 days after symptom relief. This finding highlights the importance of isolation and distancing in patients after recovery and the adoption of hygiene measures. | en |
| DOI | https://doi.org/10.5812/mejrh.115349 | en |
| Keyword | COVID-19 | en |
| Keyword | Infectivity | en |
| Keyword | Real-time PCR | en |
| Keyword | Isolation | en |
| Publisher | Brieflands | en |
| Title | Infectivity Period After Symptom Relief in SARS-CoV-2 Patients: An Experimental Trial | en |
| Type | Research Article | en |
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