Prevalence and Risk Factors for Occult Hepatitis B and HIV Infections Among HCV Infected Intravenous Drug Users, Tehran, Iran
| Author | Behnoosh Eshraghi Mosa Abadi | en |
| Author | Tahmineh Kandelouei | en |
| Author | Gita Eslami | en |
| Author | Maryam Asli | en |
| Author | Maryam Vaezjalali | en |
| Issued Date | 2018-12-31 | en |
| Abstract | Background: Exposure to hepatitis B virus (HBV) or human immunodeficiency virus (HIV) infection is common among hepatitis C virus (HCV)-infected Intra venous drug users (IVDUs); however there exist only a few data about frequency and risk factors of HCV, occult HBV infection (OBI) and HIV among IVDUs. Objectives: This study aimed to investigate the prevalence and associated risk factors for OBI and HIV infections among Iranian HCV infected IVDUs. Methods: Serum samples were screened for the presence of hepatitis C virus antibody (HCVAb), hepatitis B core antibody (HBcAb), hepatitis B surface antigen (HBsAg), and human immunodeficiency virus antibody/antigen (HIVAb/Ag) using enzyme linked immunosorbent assay (ELISA). For detection of OBI, presence of HBV DNA among HBcAb positive/HBsAg negative subjects was determined using nested polymerase chain reaction (PCR). Results: Among all subjects, 94 cases (53.5%) were positive for HCVAb from which 7% and 23.4% were positive for HCV/OBI and HCV/HIV co-infections, respectively. A significant association existed between HCVAb with type of drug, sharing syringes and needles and a history of imprisonment. In the case of HCV/OBI co-infections, the only significant correlation was between sharing a syringe and occult hepatitis B infection. Also no significant association existed between risk factors and HCV/HIV co-infections. Conclusions: the present data documented an alarming prevalence of HCV and HIV as well as co-infections among IVDUs, which emphasizes the requirement for expansion of public health interventions for this at-risk population. Despite previously high prevalence reported for HCV/HBV/HIV triple infections among IVDUs, low prevalence of triple HCV/OBI/HIV infections was obtained. The reason for this difference may be related to the effect of HCV on HBV expression in case of OBI which had been suggested previously. | en |
| DOI | https://doi.org/10.5812/archcid.3075 | en |
| Keyword | Drug User | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | Hepatitis C Virus | en |
| Keyword | Human Immunodeficiency Virus | en |
| Keyword | Iran | en |
| Publisher | Brieflands | en |
| Title | Prevalence and Risk Factors for Occult Hepatitis B and HIV Infections Among HCV Infected Intravenous Drug Users, Tehran, Iran | en |
| Type | Research Article | en |
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