Association of <i>Resistin</i> Gene Polymorphism with Type 2 Diabetes in Khuzestan Province

Abstract

Background: Genome-Wide Association Studies (GWAS) have recognized that polymorphisms of the resistin gene were strongly correlated with the risk of type 2 diabetes. Objectives: The present study aimed to investigate the association of the -420 resistin gene polymorphism with type 2 diabetes in Khuzestan province, Iran. Methods: Unrelated healthy controls (n = 200) and type 2 diabetes mellitus (T2DM) patients (n = 200) were selected from Khuzestan province, Iran. Genotyping was performed by the PCR-RFLP method. Results: The frequency of the CC genotype in diabetic patients was about twice as high as in healthy individuals (P < 0.05). The frequency of the C allele was higher in diabetics than in healthy subjects and this difference was statistically significant. Also, diabetic patients with the CC genotype had the highest fasting blood glucose and the lowest HbA1C among studied patients with other genotypes although these differences were not statistically significant (P ≥ 0.05). Conclusions: The findings showed that the resistin gene polymorphism at position -420 (C>G) gene was correlated with T2DM. In addition, the high frequency of the C allele in diabetic patients may influence susceptibility to T2DM.