Cardiovascular Manifestations of Viral Hepatitis: A Systematic Review and Meta-Analysis
| Author | Dan Li | en |
| Author | Yang Jiao | en |
| Author | Haiwei Yu | en |
| Author | Sijian Feng | en |
| Orcid | Dan Li [0009-0000-2705-1789] | en |
| Orcid | Yang Jiao [0009-0003-3245-1412] | en |
| Orcid | Haiwei Yu [0009-0007-8928-6226] | en |
| Orcid | Sijian Feng [0009-0000-8930-4980] | en |
| Issued Date | 2026-12-31 | en |
| Abstract | Background: Chronic viral hepatitis, particularly hepatitis B virus (HBV) and hepatitis C (HCV), has been associated with systemic inflammation and endothelial dysfunction, which may increase cardiovascular risk. However, the magnitude of this risk remains unclear. Objectives: This systematic review and meta-analysis aimed to quantify the association between chronic viral hepatitis and cardiovascular disease (CVD) outcomes. Methods: We searched PubMed, Scopus, and Web of Science for observational studies published from January 2019 to May 2025. Studies reporting cardiovascular events in adults with HBV or HCV were included. Data were extracted independently by two reviewers. The primary effect measure was the observed-to-expected (O/E) ratio. Meta-analysis was conducted using a random-effects model, and heterogeneity and publication bias were assessed. Results: Eight papers were included in the meta-analysis to assess the relationship between hepatitis infection and the risk of CVD. The combined O/E ratio was 1.33 (95% CI: 1.24 to 1.42), indicating a 33% increased risk of CVD in patients with hepatitis compared to expected rates in the general population. The 95% prediction interval (1.24 to 1.43) showed consistent results across studies. No significant publication bias was detected according to Egger’s test (P = 0.245), Egger’s multiplicative overdispersion test (P = 0.260), or the Macaskill test (P = 0.813). Funnel plot analyses also supported the absence of notable asymmetry. Conclusions: This meta-analysis demonstrates a significantly increased cardiovascular risk in patients with viral hepatitis, as reflected by an elevated pooled O/E ratio. | en |
| DOI | https://doi.org/10.5812/hepatmon-167192 | en |
| URI | https://brieflands.com/journals/hepatmon/articles/167192 | en |
| Keyword | Cardiovascular Diseases | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | Hepatitis C Virus | en |
| Keyword | Observed-to-Expected Ratio | en |
| Keyword | Forest Plot | en |
| Publisher | Brieflands | en |
| Title | Cardiovascular Manifestations of Viral Hepatitis: A Systematic Review and Meta-Analysis | en |
| Type | Systematic Review | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- hepatmon-26-1-167192-publish-pdf.pdf
- Size:
- 718.78 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF