Effects of Pantoprazole on Systemic and Gastric Pro- and Anti-inflammatory Cytokines in Critically Ill Patients

AuthorHamed Tabeefaren
AuthorMohammad Taghi Beigmohammadien
AuthorMohammad Reza Javadien
AuthorMohammad Abdollahien
AuthorAta Mahmoodpooren
AuthorArezoo Ahmadien
AuthorHooshyar Honarmanden
AuthorAtabak Najafien
AuthorMojtaba Mojtahedzadehen
Issued Date2012-10-31en
AbstractStress-related mucosal damage (SRMD) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. Prophylaxis of SRMD with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. Both demonstrated to be effective in reducing clinically significant bleedings, while PPIs has shown to exert some anti inflammatory effects including the inhibition of producing pro-inflammatory cytokines. As cytokines have role in developing SRMD, the aim of this study was to evaluate the effect of PPIs on the inhibition of cytokine release following the critical illness.en
DOIhttps://doi.org/10.22037/ijpr.2012.1196en
KeywordPantoprazoleen
KeywordCytokinesen
KeywordStress-related mucosal damage prophylaxisen
KeywordCritically ill patientsen
PublisherBrieflandsen
TitleEffects of Pantoprazole on Systemic and Gastric Pro- and Anti-inflammatory Cytokines in Critically Ill Patientsen
TypeOriginal Articleen

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