Effect of progressive resistance training on serum amyloid A and apolipoprotein A-I levels in diabetic Rats

Abstract

Introduction: Serum amyloid A (SAA) is an acute-phase protein, which is a clinically useful marker of inflammation and associates strongly with increased risk of cardiovascular events. The purpose of this study was to investigate the effect of resistance training with progressive load on serum levels of SAA and apolipoprotein A-I (apoA-I) in streptozotocin-induced diabetic rats. Materials and Methods: Twenty four male Wister rats (292 ± 20g) were randomly divided into three groups: non-diabetic control, diabetic control, and diabetic training. The rats in diabetic training group were subjected to a resistance training program (3 days/wk, for 4 wk) consisted of climbing a ladder carrying a load suspended from the tail. Following four weeks resistance training serum lipid profile, glucose, SAA and apoA-I concentrations were measured. Results: We did not find any significant difference in serum lipid profile between all groups. Serum levels of SAA and apoA-I were significantly higher in both diabetic groups compare with non-diabetic control group (respectively, P=0.020 ; P= 0.001). After 4 weeks of resistance training serum apoA-I levels significantly increased compared with diabetic control group (P= 0.035), but we did not find any significant difference in SAA levels between diabetic groups. Conclusion: This study indicated that resistance training could increase serum apoA-I levels in diabetic rats without significant changes in lipid profile and SAA levels. These changes may mitigate the risk for atherosclerosis progression and its clinical consequences in diabetic conditions