The Effect of Spinal and General Anesthesia on Cytokine Serum Levels Following Cesarean Section in Preeclampsia
| Author | Mohammadreza Moshari | en |
| Author | Samira Rajaei | en |
| Author | Maryam Vosoughian | en |
| Author | Hedayatollah Elyasi | en |
| Orcid | Samira Rajaei [0000-0001-8556-1525] | en |
| Orcid | Maryam Vosoughian [0000-0001-9377-3587] | en |
| Issued Date | 2018-09-30 | en |
| Abstract | ?Background: The purpose of this study is to investigate the impact of different anesthetic techniques on the release of cytokines interleukin IL-6, IL-10 and tumor necrosis factor (TNF)-? in preeclampsia patients who undergo cesarean section.Materials and Methods: In the study 40 patients were enrolled with preeclampsia undergoing cesarean section, allocated into two equal groups to receive either general anesthesia (n = 20) or spinal anesthesia (n = 20). Non-invasive hemodynamic monitoring was used. Serum levels of IL-6, IL-10 and TNF-? were measured before and at the end of surgery.Results: There was no significant rise in serum levels of TNF-? in general anesthesia while IL-6 and IL-10 serum levels increased significantly. Also, compared with patients anaesthetized with general anesthesia patients who received regional anesthesia notably had lower levels of IL-6 and IL-10 after surgery (p < 0.05).Conclusion: Spinal anesthesia causes significant difference in post-operation IL-6 and IL-10 serum levels in preeclampsia patients undergoing cesarean section. Nevertheless, neither general nor spinal anesthesia made such effect on serum level of TNF-?. Further studies with higher sample size and comparing preeclamptic patients to healthy mothers undergoing cesarean section are required. | en |
| DOI | https://doi.org/10.22037/jcma.v3i3.22580 | en |
| Keyword | Spinal Anesthesia | en |
| Keyword | Preeclamcia | en |
| Keyword | General anesthesia | en |
| Keyword | Interleukin-10 | en |
| Keyword | Interleukin-6 | en |
| Keyword | TNF-? | en |
| Keyword | Cesarean Section | en |
| Publisher | Brieflands | en |
| Title | The Effect of Spinal and General Anesthesia on Cytokine Serum Levels Following Cesarean Section in Preeclampsia | en |
| Type | Original Articles | en |
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