F-18 FDG PET-CT Influences Target Delineation When Combined With Standard CT-Based Radiotherapy Planning in the Palliative Setting in Malignant Pleural Mesothelioma; an Exploratory Study
| Author | Nicholas Mac Leod | en |
| Author | Jon Stobo | en |
| Author | Noelle O’Rourke | en |
| Author | Jonathan Hicks | en |
| Author | Karen Moore | en |
| Author | Marimuthu Sankaralingam | en |
| Author | Kurian Oommen | en |
| Author | Caroline Kelly | en |
| Author | Lynn McMahon | en |
| Author | Fat Wi Poon | en |
| Author | Sai Han | en |
| Author | Caroline Findlay | en |
| Author | Anthony Chalmers | en |
| Author | Marie Fallon | en |
| Author | Barry J. Laird | en |
| Issued Date | 2015-06-28 | en |
| Abstract | Background:: Positron emission tomography computerized tomography (PET-CT) is useful in radiotherapy planning for lung cancer. However, its role in malignant pleural mesothelioma (MPM) is unknown. Objectives:: This exploratory study investigated the possible role for PET-CT in radiotherapy planning for MPM. Patients and Methods:: Patients receiving radiotherapy for the treatment of pain in MPM, had fluorodeoxyglucose (FDG) PET-CT scanning in addition to their standard CT scan. PET-CT images were then fused with CT planning images, termed Planning-PET-CT. Target volume delineation was undertaken first using CT and subsequently incorporated Planning-PET-CT. Planning treatment volume (PTV), conformity index (CI), mean distance to conformity (MDC), center of gravity distance (CGD) and standard uptake values (SUV) were examined. Results:: Sixteen patients were recruited into the study. PET-CT upstaged nine patients. No association between SUV max and either survival or pain response was seen. Volumes contoured using Planning-PET-CT differed markedly from those outlined using CT alone as shown by the following parameters: CI = 0.3 (0.24 - 0.38). MDC = 21.47 (16.73 - 33.70) and CGD = 16.40 (11.80 - 33.87). The median percentage of over contouring was 44.00% (34.33 - 72.50) with 46.67% under contoured (34.00 - 55.00). Conclusions:: PET-CT alters the position of the PTV in MPM and upstaged a proportion of patients. Further work to elucidate the role of Planning-PET-CT in target volume definition is justified. | en |
| DOI | https://doi.org/10.17795/rro-3999 | en |
| Keyword | Positron Emission Tomography Computerized Tomography (PET-CT) | en |
| Keyword | Radiotherapy | en |
| Keyword | Mesothelioma | en |
| Publisher | Brieflands | en |
| Title | F-18 FDG PET-CT Influences Target Delineation When Combined With Standard CT-Based Radiotherapy Planning in the Palliative Setting in Malignant Pleural Mesothelioma; an Exploratory Study | en |
| Type | Research Article | en |
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