Preliminary Study on Hepatoprotective Effect and Mechanism of (-)-Epigallocatechin-3-gallate against Acetaminophen-induced Liver Injury in Rats
| Author | Yongxu Lin |
| Author | Juan Huang |
| Author | Tingfang Gao |
| Author | Yuanzi Wu |
| Author | Da Huang |
| Author | Fen Yan |
| Author | Zuquan Weng |
| Issued Date | 2021-07-31 |
| Abstract | Antipyretic acetaminophen (APAP) is a commonly used drug that generally associates with liver injury. (-)-Epigallocatechin-3-gallate (EGCG), an active polyphenol extracted from green tea, is extensively reported to have the potential to impact a variety of human diseases. However, few studies were reported regarding the protective effect of EGCG on APAP-induced liver injury and the mechanism is still unclear. In this study, in-vitro and in-vivo experiments were carried out to verify the hepatoprotective effect of EGCG against APAP-induced liver injury and explore the potential mechanism. Results indicated that EGCG effectively relieved the liver injury caused by APAP, as well as APAP-induced mitochondrial dysfunction. The protective role of EGCG was not only attributed to its antioxidant capacity; but also might be related to the protective effect on hepatic mitochondrial impairment; based on that, EGCG could improve the membrane potential and activities of the respiratory chain complexes in liver mitochondria. Our study casts a new light on the mechanism of EGCG’s hepatoprotective effect and suggests that EGCG has considerable potential in developing tonics for relieving APAP-induced liver injury. |
| DOI | https://doi.org/10.22037/ijpr.2020.112727.13918 |
| Keyword | EGCG |
| Keyword | APAP |
| Keyword | Liver Injury |
| Keyword | Mitochondria |
| Keyword | ROS |
| Publisher | Brieflands |
| Title | Preliminary Study on Hepatoprotective Effect and Mechanism of (-)-Epigallocatechin-3-gallate against Acetaminophen-induced Liver Injury in Rats |
| Type | Original Article_imported |