Brain Cancer Treatment; A Systematic Review
| Author | Touba Eslaminejad | en |
| Author | Seyed Noureddin Nematollahi-Mahani | en |
| Author | Roghayeh Ershad Sarabi | en |
| Author | Mandana Ohadi | en |
| Author | Tahereh Eslaminejad | en |
| Author | Mehdi Ansari | en |
| Author | Vida Mirzaie | en |
| Orcid | Touba Eslaminejad [0000-0001-5920-1542] | en |
| Orcid | Seyed Noureddin Nematollahi-Mahani [0000-0002-4733-1953] | en |
| Issued Date | 2022-06-30 | en |
| Abstract | Context: One of the most common aggressive and primary brain tumors is glioma. The majority of diagnoses are referred to high-grade malignant glioblastoma, which carries the worst prognosis. Still, treatment of brain tumors remains a big challenge for clinicians. This study was designed to investigate the efficacy of gene therapy in the treatment of brain cancer. Methods: Studies use genes as a therapeutic agent in brain cancer treatment even alone or in combination with other treatment methods. Full-text papers, which met the inclusion criteria, were independently assessed by two reviewers. Disagreements were resolved by consultation with a third reviewer. Results: Statistical analysis showed that 50% of the papers used a virus, 36% used polymers, and 14% used cells as carriers to transfect the genes as a therapeutic agent in brain tumor models. Data showed that the estimated size of the brain tumor was reduced by using co-treatment of the gene with one of the conventional therapies. Conclusions: According to the results, co-treatment of the gene with conventional therapies could be more effective than the monotherapy methods. | en |
| DOI | https://doi.org/10.5812/ijcm-121473 | en |
| URI | https://brieflands.com/journals/ijcm/articles/121473 | en |
| Keyword | Brain Cancer | en |
| Keyword | Glioblastoma | en |
| Keyword | Gene Therapy | en |
| Keyword | Combination Therapy | en |
| Keyword | Neoplasms | en |
| Publisher | Brieflands | en |
| Title | Brain Cancer Treatment; A Systematic Review | en |
| Type | Systematic Review | en |
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