The Effect of Oxidative Stress and Antioxidants on Men Fertility

Abstract

Background: Various factors affects men fertility and oxidative stress as an important factor which affects fertility has recently got great concern. Oxidative stress refers to conditions of imbalance between productions of reactive oxygen species (ROS) and antioxidant defense mechanism. Reactive species of oxygen, free radicals and peroxide are produced in the cell when metabolism of oxygen is incomplete in the mitochondrial respiratory chain. Materials and Methods: In this review we will consider effect of oxidative stress on male fertility and the principal antioxidant defences. Results: Factors such as hypoxia, cytokines, growth factors, chemotherapy, radio frequency waves and UV radiation can increase ROS production. Oxidative stress as one of the strongest physiological factors can lead to damage of sperm and reduction of seminal plasma quality and thereby cause infertility in men. Enzymatic and non-enzymatic defences inhibit oxidant attack. The enzymatic defense include: superoxide dismutases, glutathione peroxidases, and catalase. The non-enzymatic defences include ascorbate (vitamin C) and a-tocopherol (vitamin E), beta carotene, and albumin, which neutralize free radicals. Conclusion: Oxidative stress affects male fertility through induction of lipid peroxidation, inactivation of proteins, impair of sperm motility and DNA damage.