Antifungal Susceptibility of Non-<i>albicans Candida </i>Species in A Tertiary Care Hospital, Bulgaria
| Author | Hristina Yotova Hitkova | en |
| Author | Diana Simeonova Georgieva | en |
| Author | Preslava Mihailova Hristova | en |
| Author | Teodora Vasileva Marinova-Bulgaranova | en |
| Author | Biser Kirilov Borisov | en |
| Author | Vladimir Georgiev Popov | en |
| Orcid | Hristina Yotova Hitkova [0000-0003-4059-8337] | en |
| Orcid | Diana Simeonova Georgieva [0000-0003-1075-6437] | en |
| Orcid | Preslava Mihailova Hristova [0000-0002-6164-3566] | en |
| Orcid | Teodora Vasileva Marinova-Bulgaranova [0000-0002-0951-1961] | en |
| Orcid | Biser Kirilov Borisov [0000-0002-6828-3890] | en |
| Orcid | Vladimir Georgiev Popov [0000-0002-6632-9242] | en |
| Issued Date | 2020-08-31 | en |
| Abstract | Background: Emerging non-albicans Candida (NAC) species are a major threat because of their intrinsic or acquired resistance to routinely applied antifungal agents. Objectives: The purpose of our study was to reveal in vitro activity of nine antifungal agents against NAC isolates. Methods: A total of 67 NAC (27 Candida glabrata, 10 C. tropicalis, 6 C. krusei, 6 C. parapsilosis, 4 C. lusitaniae, 4 C. lipolytica, etc.) were identified and tested. The antifungal susceptibility was estimated on the basis of minimum inhibitory concentrations (MIC). Results: Overall, 13 species were determined, of which C. glabrata was the most common (40.3%), followed by C. tropicalis (14.9%), C. krusei, and C. parapsilosis (8.9 % each). Forty-nine NAC isolates (73.13%) demonstrated decreased susceptibility to one or more antifungals, and 18 of them were resistant to all azoles. Out of 27 C. glabrata, 12 (44.4%) were resistant to fluconazole with MICs: 32 - >128 µg/mL and 15 (55.6%) were intermediate with MICs: 8 - 16 µg/mL Non-albicans Candida revealed a good susceptibility to echinocandins. Amphotericin B resistance was found in 5.97% of the isolates. Of particular interest was the detection of 6 (8.95%) multidrug-resistant NAC, which expressed resistance to azoles and echinocandins and/or amphotericin B. Conclusions: About one-fourth of the studied NAC were resistant to all azoles. These findings as well as the detection of several multidrug-resistant isolates determine the necessity of susceptibility testing of clinically important yeast isolates and control of the antifungal drugs in our hospital. | en |
| DOI | https://doi.org/10.5812/jjm.101767 | en |
| URI | https://brieflands.com/journals/jjm/articles/101767 | en |
| Keyword | Non-<i>albicans Candida</i> | en |
| Keyword | Resistance | en |
| Keyword | Antifungal Agents | en |
| Publisher | Brieflands | en |
| Title | Antifungal Susceptibility of Non-<i>albicans Candida </i>Species in A Tertiary Care Hospital, Bulgaria | en |
| Type | Research Article | en |
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