The Study of Menin Expression as a Diagnostic Factor in HBV-Related Hepatocellular Carcinoma
| Author | Bita Moudi | en |
| Author | Zahra Heidari | en |
| Author | Hamidreza Mahmoudzadeh-Sagheb | en |
| Orcid | Bita Moudi [0000-0001-6893-625X] | en |
| Orcid | Zahra Heidari [0000-0002-3401-1619] | en |
| Orcid | Hamidreza Mahmoudzadeh-Sagheb [0000-0002-3732-2586] | en |
| Issued Date | 2020-01-08 | en |
| Abstract | Background: Liver diseases are still among the most important health problems worldwide. In order to make successful treatment, an accurate diagnosis is necessary. Objectives: In the forthcoming study, the level of menin protein expression and its relationship with early diagnosis of HBV-related HCC were studied in the liver tissue of Iranian patients. Methods: The study consisted of 30 healthy control individuals (C) and 121 patients (40 patients with HBV only, 41 patients with HCC only, and 40 patients with HBV + HCC). The level of menin expression in the liver samples of all volunteers was evaluated by IHC and qRT-PCR. Results: Statistically, the level of menin expression was different between HBV-related HCC and HBV groups. There was a significant relationship between labeling index and immunohistochemical and molecular expressions of menin. Conclusions: Results emphasized the significant relationship between menin expression and risk of HCC in patients with HBV. It was concluded that menin expressions could increase significantly in HBV-related HCC patients. | en |
| DOI | https://doi.org/10.5812/archcid.88188 | en |
| Keyword | Menin | en |
| Keyword | Hepatocellular Carcinoma | en |
| Keyword | Immunohistochemistry | en |
| Keyword | Quantitative Real-Time PCR | en |
| Publisher | Brieflands | en |
| Title | The Study of Menin Expression as a Diagnostic Factor in HBV-Related Hepatocellular Carcinoma | en |
| Type | Research Article | en |