Healthcare-Associated Infections in the NICU of a Tertiary Referral Center in Southern Iran
| Author | Roya Oboodi | en |
| Author | Alireza Asemanrafat | en |
| Author | Zahra Hashemi | en |
| Author | Marziyeh Doostfatemeh | en |
| Author | Reza Bahrami | en |
| Author | Khadijeh Sadat Najib | en |
| Author | Somayeh Zolfaghari | en |
| Author | Hamide Barzegar | en |
| Orcid | Roya Oboodi [0000-0003-1006-2291] | en |
| Orcid | Zahra Hashemi [0000-0002-3545-6337] | en |
| Orcid | Marziyeh Doostfatemeh [0000-0003-3073-2600] | en |
| Orcid | Reza Bahrami [0000-0002-8554-4562] | en |
| Orcid | Khadijeh Sadat Najib [0000-0002-0094-0145] | en |
| Orcid | Hamide Barzegar [0000-0003-1114-5937] | en |
| Issued Date | 2026-07-31 | en |
| Abstract | Background: Healthcare-associated infections (HAIs) contribute significantly to neonatal morbidity and mortality. Objectives: This study aimed to evaluate the characteristics of HAIs in neonatal intensive care units (NICUs) affiliated with Shiraz University of Medical Sciences. Methods: This retrospective cohort study was conducted from 2021 to 2023 in NICUs affiliated with Shiraz University of Medical Sciences. All neonates diagnosed with HAIs were enrolled, and data were collected from hospital records. Statistical analyses were performed using SPSS and R software, including Mann-Whitney U test, Kruskal-Wallis test, and logistic regression. Results: Among 214 neonates with HAIs, 122 had bloodstream infections (BSIs) and 66 had ventilator-associated pneumonia (VAP). The mean gestational age was 32.27 ± 4.07 weeks, and the mean birth weight was 1949.63 ± 924.85 grams. The duration of central line use and mechanical ventilation was significantly longer in the VAP group compared to the BSI group (P = 0.001 and P = 0.03, respectively). Gram-positive bacteria were slightly more common in BSI cases, while gram-negative bacteria predominated among VAP cases. Logistic regression identified lower birth weight and mechanical ventilation as significant predictors of mortality. Conclusions: HAIs remain a major concern among neonates, with mortality significantly associated with lower birth weight, prolonged mechanical ventilation, and central line use. Understanding the microbiological profile, with Gram-positive organisms being predominant in BSIs and gram-negative organisms in VAPs, can guide the selection of appropriate empiric antibiotics and improve outcomes in NICUs. | en |
| DOI | https://doi.org/10.5812/apid-166488 | en |
| URI | https://brieflands.com/journals/apid/articles/166488 | en |
| Keyword | Health Care Associated Infection | en |
| Keyword | Cross Infection | en |
| Keyword | Neonatal Intensive Care Units | en |
| Keyword | Ventilator-Associated Pneumonia | en |
| Keyword | Sepsis | en |
| Publisher | Brieflands | en |
| Title | Healthcare-Associated Infections in the NICU of a Tertiary Referral Center in Southern Iran | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- apid-14-3-166488-publish-pdf.pdf
- Size:
- 248.84 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF