Reduced Glutathione Peroxidase (GPx) Activity in Patients with Cutaneous Leishmaniasis
| Author | Marziye Pashmforosh | en |
| Author | Masoud Foroutan | en |
| Author | Shahrzad Soltani | en |
| Author | Mehdi Sagha Kahvaz | en |
| Author | Mohamad Sabaghan | en |
| Orcid | Marziye Pashmforosh [0000-0002-6697-3396] | en |
| Orcid | Masoud Foroutan [0000-0002-8661-7217] | en |
| Orcid | Shahrzad Soltani [0000-0001-9898-1297] | en |
| Orcid | Mehdi Sagha Kahvaz [0000-0003-0432-3117] | en |
| Orcid | Mohamad Sabaghan [0000-0003-4670-767X] | en |
| Issued Date | 2023-07-31 | en |
| Abstract | Background: Cutaneous leishmaniasis (CL) is a tropical parasitic infection that involves several factors in its pathogenesis, including oxidative stress. The oxidative stress in CL may deplete antioxidant nutrients. Objectives: The aim of the study was to measure glutathione peroxidase (GPx) activity in patients with CL. Methods: The investigation included 80 patients with CL and 80 healthy participants. A diagnostic kit was used to measure GPx activity. Results: The results showed a significant decrease in GPx activity in the CL patient group compared to the control group (P < 0.001), which is related to increased oxidative stress in patients. Conclusions: According to the results, GPx enzyme activity can serve as a biomarker for the diagnosis, prognosis, and monitoring of treatment in patients with CL. | en |
| DOI | https://doi.org/10.5812/chbs-147175 | en |
| Keyword | Cutaneous Leishmaniasis | en |
| Keyword | Glutathione Peroxidase | en |
| Keyword | Oxidative Stress | en |
| Keyword | Case-Control | en |
| Publisher | Brieflands | en |
| Title | Reduced Glutathione Peroxidase (GPx) Activity in Patients with Cutaneous Leishmaniasis | en |
| Type | Research Article | en |
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