The Effect of Vitamin C on Parathyroid Hormone in Patients on Hemodialysis With Secondary Hyperparathyroidism: A Double Blind, Placebo-Controlled Study
| Author | Vajihe Biniaz | en |
| Author | Eghlim Nemati | en |
| Author | Ali Tayebi | en |
| Author | Mehdi Sadeghi Shermeh | en |
| Author | Abbas Ebadi | en |
| Issued Date | 2013-11-01 | en |
| Abstract | Background: Secondary hyperparathyroidism (SHPT) is a prevalent disorder in patients with chronic kidney disease. It is proffered that there is a contradictory relation between serum level of vitamin C and parathyroid hormone (PTH) in hemodialysis patients with secondary hyperparathyroidism. Objectives: The goal of this study was to assess the effects of the supplemental vitamin C on parathyroid hormone among hemodialysis patients with secondary hyperparathyroidism. Patients and Methods: This randomized, placebo-controlled, double-blind and parallel-group trial was conducted on 82 hemodialysis patients with serum levels of PTH more than 200 pg/mL. In intervention group, 250 mg vitamin C was injected three times a week for 8 weeks in a row immediately at the end of each dialysis session via the intravenous route. In the control group, same term of placebo saline was injected. Results: The mean of serum PTH was 699.81 (± 318.8) and 596.03 (± 410.7) pg/mL in intervention and control groups respectively at baseline (reference range, 6 to 66 pg/mL), and at the end of study it changed to 441.4 and 424.6 in these groups. The values of serum Calcium and Phosphate did not significantly change during the study (8.4 ± 0.6 mg/dL versus 8.1 ± 0.8 mg/dL, P = 0.39; 5.89 ± 1.7 mg/dL versus 5.9 ± 1.9 mg/dL, P = 0.08, respectively). Conclusions: This study finding does not warranted therapeutic effect of vitamin C on secondary hyperparathyroidism. | en |
| DOI | https://doi.org/10.5812/numonthly.12404 | en |
| URI | https://brieflands.com/journals/num/articles/17073 | en |
| Keyword | Renal Dialysis | en |
| Keyword | Parathyroid Hormone | en |
| Keyword | Hyperparathyroidism | en |
| Keyword | Secondary | en |
| Keyword | Ascorbic Acid | en |
| Publisher | Brieflands | en |
| Title | The Effect of Vitamin C on Parathyroid Hormone in Patients on Hemodialysis With Secondary Hyperparathyroidism: A Double Blind, Placebo-Controlled Study | en |
| Type | Research Article | en |
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