Hepatoprotective Effect of 17β-Estradiol as Antioxidant Modulators Against Stress Damage
| Author | Can Serpil | en |
| Author | Cigsar Gulsen | en |
| Author | Gur Ozabacigil Fatma | en |
| Author | Aksak Karamese Selina | en |
| Author | Selli Jale | en |
| Author | Bacak Gulsum | en |
| Author | Gedikli Semin | en |
| Author | Gonul Zisan Sahin | en |
| Author | Yigit Serdar | en |
| Author | Can Ismail | en |
| Author | Gul Mustafa | en |
| Issued Date | 2015-02-01 | en |
| Abstract | Background: Liver is one of the most important organs affected by exercise. According to the literature a few study to date has investigated the effects of estrogen supplementation on exercise-induced oxidative stress in liver tissue of rats. Objectives: We aimed to investigate the effects of estrogen supplementation on oxidative stress markers in liver tissue of exercised rats. Materials and Methods: Male rats (n = 35) were divided as estrogen supplemented (n = 18) and non-supplemented groups (n = 17); these groups were further divided as rest and eccentric exercised groups. Eccentric exercise groups were further divided as rats killed after 1 hour and 48 hours of eccentric exercise. Estrogen (10 mg/kg) was administered subcutaneously for 30 days. Eccentric exercise was applied as treadmill run (15° downhill, 20 m/min) consisting of periods of "5 min" run and 2 min rest repeated 18 times. The rat liver was examined biochemically and histologically. Activities of GST, GSH-Px, CAT, SOD and MDA concentration were also measured spectrophotometrically. Results: Some disruptions were detected in experimental groups compared with the control group. Additionally, exercise training caused an increase in SOD and decrease in GSH-Px activities in some experimental groups. SOD activities increased significantly in group 3 (Estrogen (-), eccentric exercise (+) killed (after 1 h), compared with group 5 (Estrogen (-), eccentric exercise (+) killed (after 48 h). On the other hand, GSH-Px activities were also significantly decreased in groups 3, 4 and 5 compared with the control group. Leukocyte infiltration in liver increased after 48 hours compared with after 1 hour and estrogen supplementation was not able to prevent this infiltration. Conclusions: Estrogen seemed to be not very effective to prevent eccentric exercise-induced liver damage. | en |
| DOI | https://doi.org/10.5812/hepatmon.22633 | en |
| Keyword | Antioxidants | en |
| Keyword | Exercise | en |
| Keyword | Estrogens | en |
| Keyword | Liver | en |
| Publisher | Brieflands | en |
| Title | Hepatoprotective Effect of 17β-Estradiol as Antioxidant Modulators Against Stress Damage | en |
| Type | Research Article | en |