A Survey of Correlation Between Insulin-Like Growth Factor-I (IGF-I) Levels and Severity of Liver Cirrhosis
| Author | Asghar Khoshnood | en |
| Author | Mohsen Nasiri Toosi | en |
| Author | Mohammad Jafar Faravash | en |
| Author | Alireza Esteghamati | en |
| Author | Hosein Froutan | en |
| Author | Hadi Ghofrani | en |
| Author | Mohammad Kalani | en |
| Author | Arash Miroliaee | en |
| Author | Ahmad Abdollahi | en |
| Author | Andrabi Yasir | en |
| Issued Date | 2013-02-01 | en |
| Abstract | Background: Insulin-like growth factor is a polypeptide with endocrine, autocrine and paracrine effects which its structure is similar to the insulin molecule. While various tissues secrete IGF-1, 90% of the circulating IGF-1 is secreted by liver. Cirrhosis of liver is a condition accompanied by decreased level of IGF-1, in which the level of IGF-1 may be further decreased thorough the progression of the disease Objectives: The aim of the present study was to demonstrate the relation between the IGF-1 levels and severity of liver disease according to Child- Pugh and Model for end stage liver diseases (MELD) Scores. Patients and Method: This was a descriptive-analytic cross sectional study performed on patients with cirrhosis admitted to gastroenterology clinic of Imam Khomeini Hospital in Tehran, Iran during the years 2007-2008. The diagnosis was based on liver biopsy. Initially for all patients, laboratory investigations including IGF-1, CBC, liver Enzymes, Alkaline phosphates, serum Albumin, Creatinine, direct and total Bilirubin were conducted. Also ultrasound and endoscopy were performed for evaluation of ascites and varices. Results: 100 patients with cirrhosis with a male to Female ratio of 63:37 and a mean age of 44.4 ± 15 years were enrolled in the study. Median IGF-1 was 92.95 ± 91.51 ng/mL. 14 patients (14%) had IGF-1 within normal limits while 86 patients (86%) had abnormal IGF-1 levels. In all patients the correlation coefficient between IGF-1 and MELD was -0.317 (P = 0.001) and 0.478 between IGF-1 and Child- Pugh (P < 0.001). Conclusions: Our findings showed that IGF-1 can be used as an index for evaluating the severity of cirrhosis; also it can be used for determining the severity of the disease, when liver biopsy is not possible. | en |
| DOI | https://doi.org/10.5812/hepatmon.6181 | en |
| URI | https://brieflands.com/journals/hepatmon/articles/15186 | en |
| Keyword | Insulin-Like Growth Factor I | en |
| Keyword | Liver Cirrhosis | en |
| Keyword | Child | en |
| Publisher | Brieflands | en |
| Title | A Survey of Correlation Between Insulin-Like Growth Factor-I (IGF-I) Levels and Severity of Liver Cirrhosis | en |
| Type | Research Article | en |
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