In Vivo Wound-Healing and Anti-Inflammatory Activities of Honey Produced by <i>Melipona beecheii</i> Bees
| Author | Ina Ramírez Miranda | en |
| Author | Juan Acevedo-Fernandez | en |
| Author | Elizabeth Negrete-Leon | en |
| Author | David Abram Betancur-Ancona | en |
| Author | Yolanda Beatriz Moguel-Ordoñez | en |
| Orcid | Ina Ramírez Miranda [0000-0003-4255-0847] | en |
| Orcid | Juan Acevedo-Fernandez [0000-0001-8306-1690] | en |
| Orcid | Elizabeth Negrete-Leon [0000-0001-7065-4032] | en |
| Orcid | David Abram Betancur-Ancona [0000-0002-9206-3222] | en |
| Orcid | Yolanda Beatriz Moguel-Ordoñez [0000-0003-4805-4035] | en |
| Issued Date | 2024-05-31 | en |
| Abstract | Background: Honey produced by the Melipona beecheii bees has been highly prized in Mexico since pre-Hispanic times for its therapeutic properties, particularly in wound healing. Objectives: The aim of this study was to assess the in vivo wound-healing and anti-inflammatory effects of M. beecheii honey using an animal model. Methods: Honey samples were collected from the state of Yucatan, Mexico. Male albino mice were utilized to test the wound-healing and anti-inflammatory properties of the honey, with pirfenidone (KitosCell®) and indomethacin (1 and 30 mg/mL) serving as positive controls, respectively. Results: From day one, enhancements in wound healing, granulation tissue formation, and continuous contraction of the wound edges were observed. In terms of anti-inflammatory activity, the honey dose was capable of reducing edema comparably to the control group receiving 1 mg/mL of indomethacin. However, differences were noted when compared to the 30 mg/mL indomethacin control group in three of the groups. Conclusions: It can be concluded that M. beecheii honey exhibits wound-healing and anti-inflammatory effects comparable to those of the positive controls used in this study. Therefore, it offers a viable alternative for the topical treatment of wounds. | en |
| DOI | https://doi.org/10.5812/jjnpp-143682 | en |
| Keyword | Honey | en |
| Keyword | Stingless Bees | en |
| Keyword | Therapeutic Properties | en |
| Keyword | Animal Model | en |
| Publisher | Brieflands | en |
| Title | In Vivo Wound-Healing and Anti-Inflammatory Activities of Honey Produced by <i>Melipona beecheii</i> Bees | en |
| Type | Research Article | en |