Successful Treatment of Postneurosurgical Ventriculitis Caused by Extensively Drug-resistant <i>Acinetobacter baumannii</i> in a Child: Case Report
| Author | Rui Yang | en |
| Author | Fang Li | en |
| Author | Weiwei Mao | en |
| Author | Xin Wei | en |
| Author | Xinzhu Liu | en |
| Author | Xiaowen Guo | en |
| Author | Wentao Luo | en |
| Author | Yan Liu | en |
| Author | Jian Zhang | en |
| Orcid | Weiwei Mao [0000-0003-4790-0885] | en |
| Issued Date | 2021-12-31 | en |
| Abstract | Introduction: The incidence of postneurosurgical Acinetobacter baumannii ventriculitis/meningitis, primarily due to drug-resistant strains, has increased considerably in recent years. However, limited therapeutic options are available because most antibiotics poorly penetrate the blood-brain barrier, especially in pediatric patients. Case Presentation: A five-year-old boy developed ventriculitis due to extensively drug-resistant A. baumannii (XDRAB) after bilateral frontal external ventricular drainage for spontaneous intraventricular hemorrhage. The boy was safely and successfully treated with intraventricular (IVT)/intrathecal (ITH) polymyxin B together with intravenous tigecycline plus cefoperazone/sulbactam. Conclusions: In the present case, postneurosurgical XDRAB ventriculitis was closely associated with intraventricular hemorrhage and the placement of external ventricular drainage. IVT/ITH polymyxin B combined with intravenous tigecycline and cefoperazone sulbactam could be a therapeutic option against XDRAB ventriculitis in children. | en |
| DOI | https://doi.org/10.5812/jjm.118114 | en |
| Keyword | <i>Acinetobacter baumannii</i> | en |
| Keyword | Ventriculitis | en |
| Keyword | Pediatrics | en |
| Keyword | Tigecycline | en |
| Keyword | Polymyxin B | en |
| Publisher | Brieflands | en |
| Title | Successful Treatment of Postneurosurgical Ventriculitis Caused by Extensively Drug-resistant <i>Acinetobacter baumannii</i> in a Child: Case Report | en |
| Type | Case Report | en |