Alginate-Based Hydrogel Containing Taurine-Loaded Chitosan Nanoparticles in Biomedical Application
| Author | Arash Goodarzi | en |
| Author | Mehdi Khanmohammadi | en |
| Author | Somayeh Ebrahimi-Barough | en |
| Author | Mahmoud Azami | en |
| Author | Amir Amani | en |
| Author | Alireza Baradaran-Rafii | en |
| Author | Nasrin Lotfi bakhshaiesh | en |
| Author | Armin Ai | en |
| Author | Ali Farzin | en |
| Author | Jafar Ai | en |
| Issued Date | 2019-04-30 | en |
| Abstract | The hydrogel efficacy of taurine-loaded chitosan nanoparticle/alginate hydrogel was investigated for controlled release of the taurine substrate, which is known as an antioxidative drug. The composition of the fabricated hydrogels was explored by Fourier-transform infrared spectroscopy. The swelling ability and degradation rate of hydrogels were also analyzed in phosphate-buffered saline at the physiological condition and alginate lyase for a period of 21 days. Moreover, morphologies and structure of hydrogels and cells were determined using a scanning electron microscope. The possible cytotoxicity of the fabricated hydrogel was carried out by seeding endometrial stem cells on hydrogels. The results demonstrated that hydrogel of chitosan nanoparticle/alginate hydrogel successfully controlled the release of taurine. We observed that the chitosan nanoparticle/alginate hydrogel possessed adjust swelling ability and degradation rate as compared to neat alginate hydrogel. The results proved that the chitosan nanoparticle/alginate hydrogel is non-cytotoxic and could be utilized as a promising composition in tissue engineering and drug delivery systems. | en |
| DOI | https://doi.org/10.5812/ans.86349 | en |
| URI | https://brieflands.com/journals/ans/articles/86349 | en |
| Keyword | Alginate-Based Hydrogel | en |
| Keyword | Chitosan Nanoparticle | en |
| Keyword | Taurine | en |
| Keyword | Controlled Drug Release | en |
| Keyword | Cytocompatibility | en |
| Publisher | Brieflands | en |
| Title | Alginate-Based Hydrogel Containing Taurine-Loaded Chitosan Nanoparticles in Biomedical Application | en |
| Type | Research Article | en |