The Pharmacological Effects of Odonthobuthus doriae Scorpion Venom and Its Extracted Fractions on Neuro-Muscular Transmission
| Author | Amir Jalali |
| Author | Zahra Hossininasab |
| Author | Zynab Ehsani |
| Author | Amir-Abbas Zare |
| Author | Afshin Zarghi |
| Author | Hossein Vatanpour |
| Accessioned Date | 2023-12-27T09:47:58Z |
| Available Date | 2023-12-27T09:47:58Z |
| Issued Date | 2006-04-30 |
| Abstract | The effect of Odonthobuthos doriae (O.d) scorpion venom at 0/3, 1 and 3, 10 µg/ml concentrations were investigated on nerve-muscle transmission, using the Twitch tension technique. A concentration of 0.3 µg/ml caused a small change in the twitch height in response to indirect muscle stimulation, but higher concentrations (1, 3, 10 µg/ml) caused a transient augmentation in twitch response followed by a large contracture in the chick biventer cervices (CBC) preparation. This effect could be defined as a complex action of the venom, predominately presynaptic, in which its’ effects on postjunctional synapses is also maintained. |
| DOI | https://doi.org/10.22037/ijpr.2010.661 |
| URI | https://repository.brieflands.com/handle/123456789/56910 |
| Keyword | Scorpion venom |
| Keyword | Odonthobuthus doriae |
| Keyword | Pharmacological responses |
| Keyword | Neuro-muscular |
| Publisher | Brieflands |
| Title | The Pharmacological Effects of Odonthobuthus doriae Scorpion Venom and Its Extracted Fractions on Neuro-Muscular Transmission |
| Type | Research Article |