The Pharmacological Effects of Odonthobuthus doriae Scorpion Venom and Its Extracted Fractions on Neuro-Muscular Transmission

AuthorAmir Jalalien
AuthorZahra Hossininasaben
AuthorZynab Ehsanien
AuthorAmir-Abbas Zareen
AuthorAfshin Zarghien
AuthorHossein Vatanpouren
Accessioned Date2023-12-27T09:47:58Z
Available Date2023-12-27T09:47:58Z
Issued Date2006-04-30en
AbstractThe effect of Odonthobuthos doriae (O.d) scorpion venom at 0/3, 1 and 3, 10 µg/ml concentrations were investigated on nerve-muscle transmission, using the Twitch tension technique. A concentration of 0.3 µg/ml caused a small change in the twitch height in response to indirect muscle stimulation, but higher concentrations (1, 3, 10 µg/ml) caused a transient augmentation in twitch response followed by a large contracture in the chick biventer cervices (CBC) preparation. This effect could be defined as a complex action of the venom, predominately presynaptic, in which its’ effects on postjunctional synapses is also maintained.en
DOIhttps://doi.org/10.22037/ijpr.2010.661en
URIhttps://repository.brieflands.com/handle/123456789/56910
KeywordScorpion venomen
KeywordOdonthobuthus doriaeen
KeywordPharmacological responsesen
KeywordNeuro-muscularen
PublisherBrieflandsen
TitleThe Pharmacological Effects of Odonthobuthus doriae Scorpion Venom and Its Extracted Fractions on Neuro-Muscular Transmissionen
TypeResearch Articleen

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