Polymorphisms within the Promoter Region of the Gamma Interferon (IFN-?) Receptor1 Gene are Associated with the Susceptibility to Chronic HBV Infection in an Iranian Population
| Author | Sayyad Khanizadeh | en |
| Author | Mehrdad Ravanshad | en |
| Author | Seyed Reza Reza Mohebbi | en |
| Author | Hamed Naghoosi | en |
| Author | Mohamad Ebrahim Abrahim Tahaei | en |
| Author | Seyed Dawood Dawood Mousavi Nasab | en |
| Author | Sara Romani | en |
| Author | Pedram Azimzadeh | en |
| Author | Azar Sanati | en |
| Author | Mohammad Reza Reza Zali | en |
| Orcid | Sayyad Khanizadeh [0000-0003-1808-2481] | en |
| Orcid | Mehrdad Ravanshad [0000-0002-7020-7889] | en |
| Orcid | Seyed Reza Reza Mohebbi [0000-0002-7020-7889] | en |
| Orcid | Hamed Naghoosi [0000-0002-7020-7889] | en |
| Orcid | Mohamad Ebrahim Abrahim Tahaei [0000-0002-7020-7889] | en |
| Orcid | Seyed Dawood Dawood Mousavi Nasab [0000-0003-1808-2481] | en |
| Orcid | Sara Romani [0000-0002-7020-7889] | en |
| Orcid | Pedram Azimzadeh [0000-0002-7020-7889] | en |
| Orcid | Azar Sanati [0000-0002-7020-7889] | en |
| Orcid | Mohammad Reza Reza Zali [0000-0002-7020-7889] | en |
| Issued Date | 2012-11-06 | en |
| Abstract | Background: chronic hepatitis B virus (HBV) infection is a multifactorial disease that can result in serious clinical complications. Host genetic background especially the genes that encode immunologic factors like INF-? and its receptor (IFN-? R) are critical in the pathogenesis of infection. Objectives: The current study aimed to investigate the association between two single nucleotide polymorphisms (SNPs) at positions -611 and -56 within the promoter region of gamma interferon receptor1 gene (IFN-? R1) and chronic HBV infection. Materials and Methods: Genomic DNA from peripheral blood samples of 200 chronically HBV infected patients and 200 healthy blood donors, as controls, were collected and genomic DNA was extracted by phenol-chloroform method and DNA analysis genotype identification was performed by PCR-RFLP. Results: The results indicated that both SNPs frequency had a significant difference in the patient and control groups. At position -56, TT genotype was associated with patient group and P value was 0.002 and at position -611, GG genotype was further observed in control group and P value was 0.006. Conclusions: Presence of G allele at position -611 within promoter of IFN-? R1 gene in the enrolled population for the study was related to lower risk of disease, and presence of T allele at position -56 was also related to susceptibility to chronic HBV infection. Men had higher frequency of chronic HBV infection, which might be the result of high risk behavior. | en |
| DOI | https://doi.org/10.5812/hepatmon.7283 | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | Single Nucleotide Polymorphism | en |
| Keyword | Interferon Gamma Receptor | en |
| Keyword | Polymorphism | en |
| Keyword | Restriction Fragment Length | en |
| Publisher | Brieflands | en |
| Title | Polymorphisms within the Promoter Region of the Gamma Interferon (IFN-?) Receptor1 Gene are Associated with the Susceptibility to Chronic HBV Infection in an Iranian Population | en |
| Type | Research Article | en |
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