Association Between Uremic Pruritus and Serum Level of Fibroblast Growth Factor 23 in Hemodialysis Patients in North of Iran: An Observational Study
| Author | Seyyede Zeinab Azimi | en |
| Author | Elham Ramezanzade | en |
| Author | Narges Alizadeh | en |
| Author | Ali Monfared | en |
| Orcid | Seyyede Zeinab Azimi [0000-0001-8213-6056] | en |
| Orcid | Elham Ramezanzade [0000-0001-9415-9319] | en |
| Orcid | Narges Alizadeh [0000-0003-0850-488X] | en |
| Orcid | Ali Monfared [0000-0002-5231-1658] | en |
| Issued Date | 2022-11-30 | en |
| Abstract | Background: Chronic itch (CI) in hemodialysis (HD), also called uremic pruritus (UP), is a common, distressing, and unpleasant symptom. Fibroblast growth factor 23 (FGF23) is a bone-secreted phosphaturic factor. Several bone diseases can accompany kidney diseases. It is unclear whether the common disturbance of calcium/phosphate homeostasis can cause CI in chronic kidney disease. Objectives: This study investigated the association between FGF23 and UP among HD patients in northern Iran. Methods: Patients undergoing maintenance HD at four referral medical centers were recruited in this cross-sectional survey. The enzyme-linked immunosorbent assay was used to evaluate serum FGF23 levels. An interview questionnaire was used to analyze the various aspects of pruritus. Results: Of 237 subjects, 54.01% had UP. There was no difference in serum FGF23 levels between patients with and without UP (413.17 ± 416.97 vs. 410.81 ± 444.49, P = 0.85). Those with UP required dialysis for a longer period (P = 0.02). FGF23 was shown to be associated with parathyroid hormone in UP (P = 0.02, r = 0.41). Conclusions: There was no linear correlation between FGF23 and UP in this study. | en |
| DOI | https://doi.org/10.5812/numonthly-128834 | en |
| Keyword | Fibroblast Growth Factor 23 | en |
| Keyword | Uremic Pruritus | en |
| Keyword | Hemodialysis | en |
| Keyword | Atorvastatin | en |
| Keyword | Parathyroid Hormone | en |
| Publisher | Brieflands | en |
| Title | Association Between Uremic Pruritus and Serum Level of Fibroblast Growth Factor 23 in Hemodialysis Patients in North of Iran: An Observational Study | en |
| Type | Research Article | en |
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