Preventive Effects of NSAIDs on Lung Tissue Oxidative Damage in an Animal Sepsis Model
| Author | Azadeh Rasooli | en |
| Author | Mansoureh Abbasi | en |
| Author | Zahra Shani | en |
| Author | Reza Hajihosseini | en |
| Issued Date | 2022-03-31 | en |
| Abstract | Background/aim: Sepsis is a very heterogeneous syndrome that is caused by a dysregulated host response to infection. Inflammatory cascades have an important role in sepsis and can potentially be suppressed by anti-inflammatory compounds. So, this study was focused on the antiseptic effects of non-steroidal anti-inflammatory drugs (NSAIDs) on lung injuries based on cecal ligation and puncture (CLP) surgery. Materials and methods: Male wistar rats divided into 6 groups (n=50) as follows: Control, Laparotomy (LAP), CLP and three treatment groups. The rats were killed after 48 h and the lung tissue was subjected to antioxidant enzymes (LP (lipid peroxidation), MPO (myeloperoxidase), and GSH (Glutathione)) and inflammatory genes expression (cyclooxygenase-2 (COX-2), CD177 and MPO). Results: The results indicated that CLP caused lung injury by changes in antioxidant enzymes and genes expression (P | en |
| DOI | https://doi.org/10.22037/jcma.v7i1.35259 | en |
| URI | https://brieflands.com/journals/jcma/articles/149696 | en |
| Keyword | Sepsis | en |
| Keyword | Anti-inflammatory compounds | en |
| Keyword | Antioxidant enzymes | en |
| Keyword | CLP | en |
| Publisher | Brieflands | en |
| Title | Preventive Effects of NSAIDs on Lung Tissue Oxidative Damage in an Animal Sepsis Model | en |
| Type | Original Articles | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 168242.pdf
- Size:
- 786.46 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF