Cetuximab-decorated and NIR-activated Nanoparticles Based on Platinum(IV)-prodrug: Preparation, Characterization and <i>In-vitro</i> Anticancer Activity in Epidermoid Carcinoma Cells
| Author | Yu Wang | en |
| Author | Xin-Ming Zhang | en |
| Author | Yu Sun | en |
| Author | Hui-Lin Chen | en |
| Author | Ling-Yun Zhou | en |
| Issued Date | 2021-01-31 | en |
| Abstract | Platinum-based drugs are the mainstay of chemotherapy regimens in a clinic, but their use is seriously limited by severe side effects and drug resistance. A cetuximab-decorated drug delivery system can selectively deliver drugs into EGFR-highexpressing cancer cells to prevent the shortcomings of platinum-based chemotherapy. Here, cetuximab-decorated and near-infrared (NIR)-activated nanoparticles based on Pt(IV)-prodrug (abbreviated as Cetuximab-Pt-INPs) was constructed. First, PEGylated Pt(IV)-prodrug was synthesized by a condensation reaction between c,c,t-[Pt(NH3)2Cl2(OOCCH2CH2COOH)(OH)] and MPEG-PLA. Then, Pt(IV)-prodrug and indocyanine green co-encapsulated nanoparticles (Pt-INPs) were prepared through an ultrasonic emulsification method. Finally, Cetuximab-Pt-INPs were obtained by decorating Pt-INPs with cetuximab as a targeting vector. The optimized Cetuximab-Pt-INPs exhibited a spherical core-shell shape of 138.5 ± 0.96 nm. In-vitro cellular uptake and cytotoxicity assays revealed that more Cetuximab-Pt-INPs with NIR irradiation were selectively taken up by A431 cells, thereby leading to higher cytotoxicity. These multifunctional nanoparticles may have promising potential for targeted and effective therapy against EGFR-highexpressing cells of epidermoid carcinoma. | en |
| DOI | https://doi.org/10.22037/ijpr.2020.113439.14303 | en |
| Keyword | Nanoparticles | en |
| Keyword | Cetuximab | en |
| Keyword | Targeted drug delivery | en |
| Keyword | Near-infrared irradiation | en |
| Keyword | Pt(IV)-prodrug | en |
| Publisher | Brieflands | en |
| Title | Cetuximab-decorated and NIR-activated Nanoparticles Based on Platinum(IV)-prodrug: Preparation, Characterization and <i>In-vitro</i> Anticancer Activity in Epidermoid Carcinoma Cells | en |
| Type | Original Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijpr-20-371.pdf
- Size:
- 1016.91 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF