Effects of Curcumin on Reproductive Parameters in Male Mice

Abstract

Backgrand: Infertility is a health problem that causes adverse effects in personal, social and economic domains. Infertility in males has been associated with sperm dysfunctions such as low sperm count, immaturity, abnormality and lack of motilty. The color of turmeric is because of a substance called curcumin for which some anti-oxidative and anti-inflammatory properties have been identified. Although researchers have reported the anti-oxidant properties of curcumin, its effects on reproductive hormones, epididymis pathway, and sperm count and motility in nicotine-infected rats have not been investigated. Methodes In this study, various doses of curcumin (10, 30 and 60 mg/kg) were administered intraperitoneally to male mice for 28 consequent days and reproductive parameters as testosterone hormone, motility, morphology, testis weight and histology were analyzed and compared. Results: The results indicated that increasing the dose of curcumin significantly increased reproductive indices such as sperm count, motility, testis weight and testosterone hormone in most of the groups (P≤05). Conclusions: It seems that curcumin increase the quality and quantity of reproductive indices in male mice.