Preparation and Optimization OF Palm-Based Lipid Nanoparticles Loaded with Griseofulvin
| Author | Wen Huei Lim |
| Author | Yann Jean Tan |
| Author | Choy Sin Lee |
| Author | Hui Meng Er |
| Author | Shew Fung Wong |
| Issued Date | 2017-04-30 |
| Abstract | Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by solvent-free hot homogenization method. The griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation, by altering the high pressure homogenisation (HPH) parameters, screening on palm-based lipids and Tween series surfactants and selection of lipid to surfactant ratios. A HPLC method has been validated for the drug loading capacity study. The optimum HPH parameter was determined to be 1500 bar with 5 cycles and among the palm-based lipid materials; Lipid C (triglycerides) was selected for the preparation of lipid nanoparticles. Tween 80 was chosen from the Tween series surfactants for its highest saturated solubility of griseofulvin at 53.1 ± 2.16 µg/mL. The optimum formulation of the griseofulvin loaded lipid nanoparticles demonstrated nano-range of particle size (179.8 nm) with intermediate distribution index (PDI) of 0.306, zeta potential of -27.9 mV and drug loading of 0.77%. The formulation was stable upon storage for 1 month at room temperature (25 °C) and 45 °C with consistent drug loading capacity. |
| DOI | https://doi.org/10.22037/ijpr.2017.1946 |
| Keyword | Lipid nanoparticles |
| Keyword | Palm |
| Keyword | Griseofulvin |
| Keyword | Particle size |
| Keyword | Drug loading |
| Keyword | Stability |
| Keyword | Zeta potential |
| Publisher | Brieflands |
| Title | Preparation and Optimization OF Palm-Based Lipid Nanoparticles Loaded with Griseofulvin |
| Type | Original Article_imported |
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