Association Between Serum Lipid Profile and Clinicopathological Features in Breast Cancer Patients

Abstract

Background: Breast cancer (BC) is the most common malignancy among women worldwide. Deregulated cellular metabolism, including lipid metabolism, is a hallmark of cancer. Alterations in serum lipid profiles have also been reported in patients with cancer. Objectives: This study aimed to investigate serum lipid profiles and their association with the clinicopathological tumor features. Methods: In this study, 55 fresh blood samples were collected to analyze serum lipid profiles using enzymatic methods. Histological data, including tumor size, grade, and stage, were recorded by a pathologist. Ki-67 nuclear expression was also assessed using immunohistochemistry. Results: The results showed positive correlations between age and high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC). Negative correlations were also observed between tumor grade and triglycerides (TG), HDL-C, and TC, as well as between ki-67 and TG, LDL-C, and TC. Conclusions: The results suggest that components of the serum lipid profile are associated with clinicopathological tumor features. Therefore, these components may have potential prognostic value or potential therapeutic targets; however, further studies are needed to confirm these findings.