Evaluation of Oxidative Stress in Patients with Fracture Admitted to Khatam Al-Anbia Hospital in Zahedan
| Author | Mansour Karajibani | en |
| Author | Farzaneh Montazerifar | en |
| Author | Faezeh Kazemi | en |
| Author | Ali Reza Dashipour | en |
| Orcid | Mansour Karajibani [0000-0002-9032-9330] | en |
| Orcid | Farzaneh Montazerifar [0000-0001-5065-5724] | en |
| Orcid | Faezeh Kazemi [0000-0002-2026-8413] | en |
| Orcid | Ali Reza Dashipour [0000-0002-4024-0012] | en |
| Issued Date | 2020-09-30 | en |
| Abstract | Background: Caused by an imbalance in the body’s oxidant and antioxidant status, oxidative stress can give rise to tissue damage and exacerbation of many diseases. Objectives: This study investigated the oxidative stress markers in patients with fractures and healthy subjects. Methods: In a cross-sectional case-control study, 40 patients with fractures admitted to an orthopedic ward and 40 healthy, non-fractured patients were selected using convenience sampling. Serum was analyzed for oxidant and antioxidant activities based on standard methods. P < 0.05 was considered statistically significant. Results: There was a significant difference in mean TAC between the case (748.2 ± 302.83 μmol/L) and control (984.90 ± 207.02 μmol/L) groups (P = 0.003). The mean MDA was 16.61 ± 4.16 µmol/L in the case group and 18.45 ± 5.43 µmol/L in the control group (P = 0.09). The mean SOD was 63.41 ± 16.67 U/g Hb in the case group and 58.54 ± 21.83 U/g Hb in the control group (P = 0.2). There was no significant difference between the two groups in terms of BMI and other variables. Conclusions: A significant difference existed in TAC between the two groups, which indicated increased oxidative stress in patients. However, oxidative stress could occur before and after undergoing fractures. The results suggested a slight, but not significant, difference between the two groups in the SOD and MDA scores. More conclusive results are required to determine the enzymatic and non-enzymatic markers of oxidative stress in larger sample sizes and during different stages of treatment. | en |
| DOI | https://doi.org/10.5812/amh.108052 | en |
| Keyword | Oxidative Stress | en |
| Keyword | Reactive Oxygen Species (ROS) | en |
| Keyword | Fracture | en |
| Publisher | Brieflands | en |
| Title | Evaluation of Oxidative Stress in Patients with Fracture Admitted to Khatam Al-Anbia Hospital in Zahedan | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- amhsr-18-3-108052.pdf
- Size:
- 199.17 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF