Safety and Effectiveness of Percutaneous Ethanol Injection as a Treatment for Locally Recurrent Papillary Thyroid Carcinoma
| Author | Amin Momeni Moghaddam | en |
| Author | Mahsa Abbaszadeh | en |
| Author | Vajihe Chavoshi | en |
| Author | Amir Ebadinejad | en |
| Author | Nafiseh Hassanloo | en |
| Author | Farhad Hosseinpanah | en |
| Orcid | Amin Momeni Moghaddam [0000-0001-7911-3531] | en |
| Orcid | Mahsa Abbaszadeh [0000-0003-2748-6111] | en |
| Orcid | Vajihe Chavoshi [0000-0001-7527-9251] | en |
| Orcid | Amir Ebadinejad [0000-0002-3147-6103] | en |
| Orcid | Nafiseh Hassanloo [0009-0001-0342-6491] | en |
| Orcid | Farhad Hosseinpanah [0000-0001-5235-9451] | en |
| Issued Date | 2024-07-31 | en |
| Abstract | Background: Reoperation for recurrent papillary thyroid cancer (PTC) is associated with a high risk of complications and limited success in achieving sustained remission. Percutaneous ethanol injection (PEI) presents a potential non-surgical alternative for managing locally recurrent PTC. Objectives: This study aimed to evaluate the safety and effectiveness of PEI in treating recurrent PTC. Methods: From October 2017 to September 2021, PEI was administered to 39 recurrent lesions (23 lateral and 16 central) in 17 patients with PTC. The median follow-up duration was 21.4 months (range, 4.1 - 37.9), with ethanol injections delivered every 3 months under ultrasound (US) guidance as needed. Results: Most patients tolerated the treatment well, experiencing only mild local pain, though one patient reported Horner syndrome following the procedure. In terms of treatment frequency, 31 lesions required 3 or fewer injections, while the remaining lesions required more. The mean initial volume of the lesions decreased from 0.12 mm³ (range: 0.06 - 0.34 mm³) to 0.03 mm³ (range: 0.0 - 0.14 mm³), representing an average reduction of 72.6% (range: 20.0 - 100.0%). Of the 39 lymph nodes treated in 17 patients, 21 lymph nodes (54%) were completely resolved. Seven lymph nodes remain under ongoing ethanol treatment, while 11 lymph nodes in 4 patients were addressed with alternative treatments, including surgery. Conclusions: Percutaneous ethanol injection appears to be a safe and effective treatment option for managing locally recurrent thyroid carcinomas in select patients. However, further comparative, prospective, long-term studies are needed to evaluate PEI’s impact on patient survival and recurrence rates. | en |
| DOI | https://doi.org/10.5812/ijem-151696 | en |
| Keyword | Percutaneous Ethanol Injection | en |
| Keyword | Papillary Thyroid Carcinoma | en |
| Keyword | Thyroid Nodule | en |
| Publisher | Brieflands | en |
| Title | Safety and Effectiveness of Percutaneous Ethanol Injection as a Treatment for Locally Recurrent Papillary Thyroid Carcinoma | en |
| Type | Research Article | en |
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