Introduce a model for diffuse brain injury in rats

Simple item page
AuthorBahram Bibaken
AuthorMohammad Khaksarien
AuthorMohammad Badvien
Issued Date2007-03-31en
AbstractIntroduction: Diffuse brain injury occurs in nearly half of all severe of clinical traumatic brain injuries and has been associated with high mortality. Brain edema is a mortal pathological condition, which is commonly observed in diffuse brain trauma. In the current study, a new model producing diffuse brain injury, without focal brain lesions, was developed in rats, for first time in Iran. Matrials and Methods: Diffuse brain trauma was produced in 45 male rats that they were divided into three groups control, sham, and trauma group. Rats in two later groups underwent general anesthesia using a mixture of halothane, oxygen and nitrous oxide. A stainless steel disc (1cm in diameter) was firmly fixed to central portion of skull vault using dental acrylic. In the trauma group, a weight of 450g was allowed to drop from the 2m height onto the disc when trauma device was ready. All animal were mechanically ventilated during the treatment. In all groups, pathological studies and measurement of brain edema were performed at 24 hours following injury. Brain edema was evaluated by water content of brain and extravasation of Evans blue (E.B) dye. Results: The results of present study indicated that this technique induces a diffuse brain injury in the rats, as it was shown by a siginificant increase of brain water content in the trauma group compared to the control and the sham groups (pen
DOIhttps://doi.org/en
KeywordBrain trauma, Water content, Evans blue content, Brain edemaen
Keywordترومای مغزی، محتوای آب، محتوای رنگ آبی ایوانز، خیز مغزیen
PublisherBrieflandsen
TitleIntroduce a model for diffuse brain injury in ratsen
TypeResearch Articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
article-1-61-fa.pdf.pdf
Size:
290.55 KB
Format:
Adobe Portable Document Format
Description:
Article/s PDF
Download

Collections

Koomesh