Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of Tongue Neoplasms in Rat
| Author | Fateme Arbabi-Kalati | en |
| Author | Mehran Mesgari-Abbasi | en |
| Author | Mojgan Nasirinasab | en |
| Author | Maryam Sohrabi | en |
| Author | Leila Roshangar | en |
| Author | Jafar Soleimanirad | en |
| Author | Amir A. Khaki | en |
| Author | Yousof Doustar | en |
| Author | Yousof Javadzade | en |
| Issued Date | 2013-01-31 | en |
| Abstract | Background : Cyclo-oxygenase-2 (COX-2) specific inhibitors were examined for predication or treatment of different tumors and it is indicated that COX-2 specific inhibitors play an important regulatory role in apoptosis of tumoral tissues. Therefore, the present study was designed in order to examine the preventive effects of a COX-2 specific inhibitor called celecoxib on 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinoma on rat.Materials and Methods : In this experimental study, 30 Sprague Dawley rats (with the age of 3- 3.5 months) were selected and divided into three groups. In order to induce lingual carcinoma, 4NQO powder was prepared 3 times a week for each cage. In this study, celecoxib power was mixed with a basic food (basal diet) in order to examine the systematic effect. Tongue samples were sent to laboratory for immunohistochemical (IHC) staining and histological examination.Results : Based on morphological criteria and the ratio of apoptosis to cell proliferation, the prevalence of tongue precancerous lesions was reduced significantly by celecoxib.Conclusion : Celecoxib systematic has inhibitory effects on the 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinoma of tongue. The effect of celecoxib is probably via suppression of cell proliferation and induction of apoptosis. | en |
| DOI | https://doi.org/ | en |
| Keyword | Chemoprevention | en |
| Keyword | Cox2 Inhibitor | en |
| Keyword | Oral Cancer | en |
| Publisher | Brieflands | en |
| Title | Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of Tongue Neoplasms in Rat | en |
| Type | Research Article | en |
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