Association of the Promoter Methylation of Mitochondrial Transcription Factor A With Susceptibility to Metabolic Syndrome
| Author | Mohammad Hashemi | en |
| Author | Hamzeh Rezaei | en |
| Author | Mahmoud Ali Kaykhaei | en |
| Author | Mohsen Taheri | en |
| Orcid | Mohammad Hashemi [0000-0002-6074-7101] | en |
| Issued Date | 2014-04-01 | en |
| Abstract | Background: It has been proposed that the patients with mitochondrial diseases usually manifest systemic metabolic disorders. The metabolic syndrome (MeS), a cluster of several metabolic disorders, is increasingly being recognized as a risk factor for type 2 diabetes (T2D) and cardiovascular disease. Objectives: The aim of study was to investigate the possible association between promoter methylation of mitochondrial transcription factor A (TFAM) and MeS. Patients and Methods: DNA was extracted from peripheral blood of 151 patients with and 149 without MeS. Results: TFAM promoter methylation was evaluated by a nested methylation-specific PCR (nested MSP). Conclusions: No association was found between TFAM promoter methylation and MeS. The present study suggests that the TFAM promoter methylation is not associated with risk of MeS. | en |
| DOI | https://doi.org/10.17795/gct-18308 | en |
| Keyword | Metabolic Syndrome X | en |
| Keyword | Mitochondrial Transcription Factor A | en |
| Keyword | Diabetes Mellitus | en |
| Keyword | Type 2 DM | en |
| Publisher | Brieflands | en |
| Title | Association of the Promoter Methylation of Mitochondrial Transcription Factor A With Susceptibility to Metabolic Syndrome | en |
| Type | Research Article | en |
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