Association of the Promoter Methylation of Mitochondrial Transcription Factor A With Susceptibility to Metabolic Syndrome

Abstract

Background: It has been proposed that the patients with mitochondrial diseases usually manifest systemic metabolic disorders. The metabolic syndrome (MeS), a cluster of several metabolic disorders, is increasingly being recognized as a risk factor for type 2 diabetes (T2D) and cardiovascular disease. Objectives: The aim of study was to investigate the possible association between promoter methylation of mitochondrial transcription factor A (TFAM) and MeS. Patients and Methods: DNA was extracted from peripheral blood of 151 patients with and 149 without MeS. Results: TFAM promoter methylation was evaluated by a nested methylation-specific PCR (nested MSP). Conclusions: No association was found between TFAM promoter methylation and MeS. The present study suggests that the TFAM promoter methylation is not associated with risk of MeS.