COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series
| Author | Alfonso Papa | en |
| Author | Anna Maria Salzano | en |
| Author | Maria Teresa Di Dato | en |
| Author | Giuliano Lo Bianco | en |
| Author | Mariangela Tedesco | en |
| Author | Antonio Salzano | en |
| Author | Dariusz Myrcik | en |
| Author | Farnad Imani | en |
| Author | Giustino Varrassi | en |
| Author | Ghodrat Akhavan Akbari | en |
| Author | Antonella Paladini | en |
| Orcid | Alfonso Papa [0000-0003-4489-714X] | en |
| Orcid | Giuliano Lo Bianco [0000-0003-2705-1548] | en |
| Orcid | Farnad Imani [0000-0003-0814-0772] | en |
| Orcid | Giustino Varrassi [0000-0002-3822-2923] | en |
| Orcid | Antonella Paladini [0000-0002-1219-9315] | en |
| Issued Date | 2021-04-30 | en |
| Abstract | Background: A variety of skin manifestations have been associated with COVID-19 infection. Acral lesions on hands and feet, closely resembling chilblains, have been reported in association with COVID-19, which are nonspecific. These acro-ischemic painful lesions have been described mainly in asymptomatic and mildly symptomatic pediatric COVID-19 positive patients, without a precise pathogenetic mechanism. COVID-19-induced chilblains may portend an indolent course and a good outcome. In young patients, the IFN-1 response induces microangiopathic changes and produces a chilblain lupus erythematosus-like eruption with vasculitic neuropathic pain features. Objectives: This paper presented a case series of pediatric patients with COVID-19-related skin lesions and neuropathic-like pain. Methods: Clinical outcomes were collected from 11 patients diagnosed with painful erythematous skin lesions with neuropathic-like pain and positive IgG for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Results: It is a mildly symptomatic condition not related to severe pain rates, and it is treated with paracetamol due to the transitory nature of the problem, which provides good results. Conclusions: A particular point of interest is skin lesion manifestation as a further indirect sign of SARS-CoV-2 infection. Due to the initial manifestation of chilblains in pauci-symptomatic pediatric patients, they need to be immediately tested and isolated. Chilblains can be considered a clinical clue to suspect SARS-CoV-2 infection and help in early diagnosis, patient triage, and infection control. | en |
| DOI | https://doi.org/10.5812/aapm.113760 | en |
| Keyword | COVID-19 | en |
| Keyword | Child, Vasculitis | en |
| Keyword | Neuropathic-like Pain | en |
| Keyword | Coronavirus | en |
| Publisher | Brieflands | en |
| Title | COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series | en |
| Type | Research Article | en |