Effect of Osthole on the Control of Listeriosis

Abstract

Background: Listeria monocytogenes is the causal agent of listeriosis, a foodborne infection. Objectives: Osthole has antibacterial properties, but its mechanisms of action is still unknown. Materials and Methods: Two millimoles of osthole was inoculated in the broth culture of Listeria monocytogenes. To study the mechanism of action, the ATP levels of cells were measured. Results: Listeria monocytogenes was controlled using 2 mM of osthole. Treatment of L. monocytogenes by 2 mM osthole had no effect on the ATP level. Conclusions: Probable mechanism of suppression of energy generation is suppression of the rise in glucose.