The molecular analysis of mutations in exons 4, 11 and 21 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in cystic fibrosis patients in Kermanshah, Iran

AuthorNasibe Karimi
AuthorAli Bidmeshkipour
AuthorKeyghobad Ghadiri
AuthorReza Alibakhshi
Issued Date2017-03-20
AbstractIntroduction: Cystic fibrosis (CF) is a common genetic disorder in white populations with an autosomal recessive pattern, caused by mutations in the CFTR gene. The frequency of more than 1950 various mutations reported in the CFTR gene significantly varies in different populations. ∆F508 is a common mutation in exon 10, which is first addressed in the molecular analysis of the disease. Other exons are required to be investigated owing to failing to identify mutations in the patients. The present study was conducted to investigate mutations in exons 4, 11 and 21 of the CFTR gene using the sequencing method in CF patients in Kermanshah province, Iran.
DOIhttps://doi.org/10.22110/jkums.v20i4.2466
KeywordCF
KeywordKermanshah
Keyword4029>G
KeywordD110H
KeywordCFTR
PublisherBrieflands
TitleThe molecular analysis of mutations in exons 4, 11 and 21 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in cystic fibrosis patients in Kermanshah, Iran
TypeResearch Article
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