The Association of Vitamin D Receptor Gene Polymorphism with Polycystic Ovary Syndrome in a Southeast Iranian Population
| Author | Marzieh Ghasemi | en |
| Author | Marzieh Koohestani | en |
| Author | Anoosh Naghavi | en |
| Orcid | Marzieh Ghasemi [0000-0001-9479-0119] | en |
| Orcid | Anoosh Naghavi [0000-0002-2358-8084] | en |
| Issued Date | 2024-07-31 | en |
| Abstract | Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age, characterized by hyperandrogenism, amenorrhea, and polycystic ovaries. Metabolic disorders, including insulin resistance (IR), are common comorbidities of PCOS, with vitamin D receptors playing a crucial role. Objectives: We investigated whether the rs2228570T > C variant of the vitamin D receptor (VDR) gene is associated with the risk of PCOS. Methods: In the current study, 112 women with PCOS and 150 healthy women participated. Genomic DNA was extracted using the standard salting-out method. Genotyping of rs2228570T > C was conducted via amplification-refractory mutation system polymerase chain reaction. Additionally, VD3 levels were measured using the ELISA system. Statistical analysis of genotyping data was performed using the SPSS V.22 package. Results: The statistical analysis showed that the T-allele of rs2228570C/T significantly decreased the risk of PCOS. Moreover, the T-allele in the codominant model significantly eliminated the risk of PCOS in our population. Our results also showed a statistically significant difference in VD3 levels between the CC and TT genotypes. Conclusions: Based on our result, rs228570C/T had a protective role for PCOS risk in our population. | en |
| DOI | https://doi.org/10.5812/gct-144633 | en |
| Keyword | Polycystic Ovary Syndrome | en |
| Keyword | Vitamin D Receptor | en |
| Keyword | Metabolic Disorders | en |
| Keyword | Single Nucleotide Polymorphism | en |
| Publisher | Brieflands | en |
| Title | The Association of Vitamin D Receptor Gene Polymorphism with Polycystic Ovary Syndrome in a Southeast Iranian Population | en |
| Type | Research Article | en |
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