Histopathological Evaluation of the Effectiveness of Glycyrrhizic Acid as a Radioprotector Against the Development of Radiation-Induced Lung Fibrosis
| Author | Soheila Refahi | en |
| Author | Bagher Minaei | en |
| Author | Gholam Hassan Haddadi | en |
| Author | Samideh Khoei | en |
| Author | Azam Bakhtiarian | en |
| Author | Masoud Pourissa | en |
| Author | Abbas Takavar | en |
| Issued Date | 2016-04-01 | en |
| Abstract | Background: Radiotherapy of the thorax often causes lung inflammation leading to fibrosis. Objectives: The aim of this study was to investigate whether the use of glycyrrhizic acid (GLA) could improve the development of lung fibrosis in irradiated animals. Materials and Methods: Wistar rats were divided into four groups. Group A rats received thoracic irradiation. Rats in group B received GLA and irradiation. Group C received GLA and no irradiation. Group D received no GLA and irradiation. GLA was administered at a dose of 4 mg/kg body weight using an intraperitoneal injection one hour before thoracic irradiation. Radiation therapy was delivered on a Cobalt-60 unit using a single fraction of 16 Gy. The animals were sacrificed at 32 weeks following thoracic irradiation. The lungs were dissected and blind histopathological evaluation was performed. Results: Histopathologically, a decrease (statistically not significant) in the thickening of alveolar or bronchial wall, formation of fibrous bands, and superimposed collagen were noted in the animals in group B as compared to the animals in group A. Conclusion: In this experimental study, administration of GLA one hour before thoracic irradiation may be a protective agent against radiation-induced fibrosis in animals and this model could be used in future studies. | en |
| DOI | https://doi.org/10.5812/iranjradiol.21012 | en |
| Keyword | Lung fibrosis | en |
| Keyword | Radioprotector | en |
| Keyword | Glycyrrhizic Acid | en |
| Keyword | Histopathology | en |
| Publisher | Brieflands | en |
| Title | Histopathological Evaluation of the Effectiveness of Glycyrrhizic Acid as a Radioprotector Against the Development of Radiation-Induced Lung Fibrosis | en |
| Type | Research Article | en |