First Co-infection of Brucella and <i>Aspergillus niger-terreus</i> as Chronic Meningitis: A Case Report
| Author | Hamideh Moradi Shahrebabak | en |
| Author | Mehdi Nourallahzadeh | en |
| Author | Hossein Sajjad Savadkouhi | en |
| Author | Seyyed Hamid Hosseini | en |
| Author | Simin Dokht Shoaei | en |
| Orcid | Hamideh Moradi Shahrebabak [0000-0001-5056-4574] | en |
| Orcid | Mehdi Nourallahzadeh [0000-0002-3825-3682] | en |
| Orcid | Simin Dokht Shoaei [0000-0003-3127-4875] | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Introduction: Chronic meningitis is a syndrome with neurologic signs and symptoms lasting more than 4 weeks with sustained abnormal cerebrospinal fluid (CSF). It has multiple differential diagnoses as infectious, autoimmune, neoplastic, and other group diseases. It may have two etiologies and complete evaluation should be done. Here we present a co-infection of meninges with Brucella and Aspergillus. Case Presentation: The patient is a 36-year-old man with one-month neuropsychologic signs and symptoms. He had headache, vomiting, behavior disorder, and decreased level of consciousness. Cerebrospinal fluid analysis showed lymphocytic pleocytosis, low sugar, and increased protein. Brucella serology in serum and CSF was positive, concurrent with Aspergillus niger-terreus positive PCR in CSF. Conclusions: This case has 4 important points: (1) Brucella meningitis is common, and this patient is the first case of Brucella and Aspergillus co-infection; (2) Aspergillus niger or terreus meningitis alone is rare, and this patient is the first coinfection of this fungus and Brucella; (3) all possible infectious and non-infectious diseases should be evaluated, and various pathogens should be considered based on the patient’s immune status and endemicity; (4) identification of pathogenic fungal species is important to use effective drugs, contemplating antifungal sensitivity. | en |
| DOI | https://doi.org/10.5812/jkums-166096 | en |
| URI | https://brieflands.com/journals/jkums/articles/166096 | en |
| Keyword | Chronic Meningitis | en |
| Keyword | Coinfection | en |
| Keyword | Brucella | en |
| Keyword | <i>Aspergillus niger-terreus</i> | en |
| Publisher | Brieflands | en |
| Title | First Co-infection of Brucella and <i>Aspergillus niger-terreus</i> as Chronic Meningitis: A Case Report | en |
| Type | Case Report | en |
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