High Concentration of TNF-α Can Involved in Malignancy Promotion of Triple-Negative Breast Cancer Patients
| Author | Yazdan Zafari | en |
| Author | Ali Homaei | en |
| Author | Ensiyeh Bahadoran | en |
| Orcid | Yazdan Zafari [0000-0001-7207-7902] | en |
| Orcid | Ensiyeh Bahadoran [0000-0001-8299-1466] | en |
| Issued Date | 2024-09-30 | en |
| Abstract | Background: Breast cancer is the most prevalent malignancy among women. Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) play a critical role in cancer pathogenesis and malignancy. Objectives: This study aimed to evaluate serum levels of TNF-α across different subtypes and stages of breast cancer. Methods: Serum samples were collected from 114 patients with various subtypes and stages of breast cancer. Tumor necrosis factor-α levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: Serum TNF-α levels were significantly higher in patients with triple-negative breast cancer (TNBC) compared to those with other breast cancer subtypes (P < 0.0001). Additionally, TNF-α levels were markedly higher in patients with stage III carcinoma than in those with stages I and II (P < 0.0001). Among stage III TNBC patients, TNF-α concentrations were significantly higher than those in stage III patients from other groups (P < 0.05). Conclusions: Evaluating serum TNF-α concentrations can provide valuable insights for estimating cancer prognosis and guiding patient management. | en |
| DOI | https://doi.org/10.69107/jid-159095 | en |
| Keyword | TNF-α | en |
| Keyword | Cytokine | en |
| Keyword | Serum | en |
| Keyword | Breast Cancer | en |
| Publisher | Brieflands | en |
| Title | High Concentration of TNF-α Can Involved in Malignancy Promotion of Triple-Negative Breast Cancer Patients | en |
| Type | Research Article | en |
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