Overview of SARS-CoV-2 Infection and Its Potential Reactions
| Author | Esmaeil Mortaz | en |
| Author | Neda K. Dezfuli | en |
| Issued Date | 2021-05-31 | en |
| Abstract | Context: The immunopathology of SARS-CoV-2 infection in COVID-19 is not well described yet, especially regarding dysregulation of the immune system. In this mini-review, current knowledge about the SARS-CoV-2 infection and immunopathogenesis of COVID-19 disease is described. We also discuss possible induced reactions against SARS-COV-2. Evidence Acquisition: Based on the authors' experience and knowledge, the current review aimed to, firstly, discuss and overview SRAS-CoV-2 infection and reactions in the body, and, secondly, to obtain related subjects from the PubMed database. Results and Conclusion: In most COVID-19 patients, uncontrollable cytokines secretion and mediators are major key points in the pathogenesis of the disease. Of all cytokines and mediators, serum levels of IL-6, IL-1β, TNF-α, IL-8, and soluble TNF-α receptor (sTNFR) have been reported. Lymphopenia and hypoxia, as well as the severity of the disease, can be considered as COVID-19 manifestations. High levels of intracellular NO inside of the red blood cells (RBCs) of patients drive the unexpected silent hypoxia phenotype induced ARDS importantly related to the patient's immune system dysfunction. | en |
| DOI | https://doi.org/10.5812/tms.115161 | en |
| Keyword | COVID-19 | en |
| Keyword | sTNFRI | en |
| Keyword | Cytokine Storm | en |
| Keyword | SARS-CoV2 | en |
| Keyword | Hypoxia | en |
| Publisher | Brieflands | en |
| Title | Overview of SARS-CoV-2 Infection and Its Potential Reactions | en |
| Type | Review Article | en |
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