Association Between HDL2-C and HDL3-C with Cardiovascular Disease: A Nested Case-Control Study in an Iranian Population
| Author | Abdolreza Chary | en |
| Author | Maryam Tohidi | en |
| Author | Mitra Hasheminia | en |
| Author | Melika Golmohammadi | en |
| Author | Reza Haji Hosseini | en |
| Author | Mehdi Hedayati | en |
| Author | Fereidoun Azizi | en |
| Author | Farzad Hadaegh | en |
| Orcid | Maryam Tohidi [0000-0003-3090-9904] | en |
| Orcid | Melika Golmohammadi [0000-0002-6063-2857] | en |
| Orcid | Reza Haji Hosseini [0000-0003-0953-233X] | en |
| Orcid | Mehdi Hedayati [0000-0001-5816-775X] | en |
| Orcid | Fereidoun Azizi [0000-0002-6470-2517] | en |
| Orcid | Farzad Hadaegh [0000-0002-8935-2744] | en |
| Issued Date | 2024-01-31 | en |
| Abstract | Background: The contribution of high-density lipoprotein cholesterol (HDL-C) subclasses to incident cardiovascular disease (CVD) and coronary heart disease (CHD) remains a subject of debate. Objectives: The objective of this study was to investigate these associations in a population with a high prevalence of dyslipidemia and CVD. Methods: In a nested case-control study, HDL-C and its subclasses (HDL2-C and HDL3-C) in 370 age and gender-matched case and control subjects were determined. This study employed multivariable-adjusted conditional logistic regression to calculate the odds ratios (ORs) for the associations between HDL-C, HDL2-C, HDL3-C, and HDL2-C/HDL3-C (both as continuous and categorical variables) with incident CVD and CHD. The present study models were adjusted for a comprehensive set of confounders, including body mass index, current smoking, hypertension, type 2 diabetes mellitus, use of lipid-lowering drugs, family history of premature CVD, non-HDL-C, and triglycerides. Results: In multivariate analysis, when considering lipoprotein parameters as continuous variables, a 1-unit increase in HDL-C and HDL3-C was associated with a reduced risk of incident CVD and CHD. For CVD, the ORs (95% confidence intervals [CI]) were 0.95 (0.92 - 0.98) and 0.95 (0.93 - 0.98) for HDL-C and HDL3-C, respectively. The corresponding values for CHD were 0.94 (0.91 - 0.97) and 0.94 (0.91 - 0.97). In the categorical approach to lipoprotein parameters, higher quartiles of HDL-C and HDL3-C, compared to the first quartile, were significantly associated with a lower risk of incident CVD and CHD. The ORs (95% CI) for the fourth quartiles were 0.43 (0.25 - 0.74, P for trend = 0.003) and 0.46 (0.27 - 0.78, P for trend = 0.005) for HDL-C and HDL3-C regarding CVD and 0.32 (0.17 - 0.59) and 0.32 (0.18 - 0.59) (all P for trend = 0.001) regarding CHD, respectively. Paradoxically, across quartiles of HDL2-C/HDL3-C, this lipid ratio was associated with a higher risk of CHD (92% higher risk in the fourth quartile). Conclusions: The results showed that HDL3-C, but not HDL2-C, was primarily responsible for the protective effect of HDL-C against CVD, particularly CHD, in Iranian adults. | en |
| DOI | https://doi.org/10.5812/ijem-141550 | en |
| Keyword | Cardiovascular Disease | en |
| Keyword | Coronary Heart Disease | en |
| Keyword | High-Density Lipoprotein | en |
| Keyword | Subclass | en |
| Keyword | HDL2-C | en |
| Keyword | HDL3-C | en |
| Publisher | Brieflands | en |
| Title | Association Between HDL2-C and HDL3-C with Cardiovascular Disease: A Nested Case-Control Study in an Iranian Population | en |
| Type | Research Article | en |
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