A Novel Electrochemical Sensor Based on MnO<sub>2</sub>/Sepiolite Nanocomposite for the Detection of Hydrogen Peroxide in Human Serum Samples
| Author | AbduRahman Hosseinifar | en |
| Author | Masoud Ghanei-Motlagh | en |
| Author | Maryam Fayazi | en |
| Orcid | Masoud Ghanei-Motlagh [0000-0002-7438-1972] | en |
| Issued Date | 2021-09-30 | en |
| Abstract | Background: The reliable and easy-to-operate detection of hydrogen peroxide (H2O2) has attracted extensive attention in the fields of biomedicine, food security, and environmental analysis. Objectives: In this work, a novel electrochemical method was proposed for H2O2 monitoring using a carbon paste electrode (CPE) modified with MnO2/sepiolite nanocomposite. Methods: MnO2/sepiolite material was characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD) technique. The modified CPE was employed for the amperometric monitoring of H2O2 in human serum samples. Results: Electrochemical data showed that the MnO2/sepiolite-CPE displays a high peak current towards H2O2 oxidation. A linear range from 5 to 700 μM and a low detection limit of 0.8 μM for H2O2 were obtained with the proposed sensor. Besides, the electrode depicted excellent reproducibility and anti-interferant ability, promising the applicability of this electrochemical method in practical analyses. Conclusions: This work introduced a new and effective enzyme-less H2O2 sensor based on the MnO2/sepiolite nanocomposite modified CPE. The suggested sensor showed good sensitivity for the rapid detection of H2O2 in a wide linear range with a low detection limit and satisfactory reproducibility, which made it practical for the analysis of hydrogen H2O2 in real samples. | en |
| DOI | https://doi.org/10.5812/amh.119100 | en |
| Keyword | Nanocomposite | en |
| Keyword | Hydrogen peroxide | en |
| Keyword | Sensor | en |
| Keyword | Human Serum | en |
| Publisher | Brieflands | en |
| Title | A Novel Electrochemical Sensor Based on MnO<sub>2</sub>/Sepiolite Nanocomposite for the Detection of Hydrogen Peroxide in Human Serum Samples | en |
| Type | Research Article | en |