Clinical Outcomes of Patients with Parkinson’s Disease with Ventilator Dependency

Abstract

Background: Parkinson's disease (PD) is a progressive neurological disorder that causes damage to dopamine neurons in the substantia nigra of the brain. Objectives: Considering the complications caused by PD, this study was conducted to determine the clinical outcomes of patients with PD who are ventilator-dependent. Methods: This case-control study (registry data) was conducted among hospitalized patients with underlying PD and a control group. The study included intubated patients who were definitively diagnosed with PD. Researchers completed patient data according to a registry checklist, which included demographic information and registry data. After collecting the information, the data were entered into SPSS version 16 software for analysis. Results: In this study, 16 patients with PD were placed in the case group, and 36 patients with other neurological disorders hospitalized in the ICU were placed in the control group. The findings showed a comparison of clinical and laboratory indicators between the PD group and the control group. According to the findings, there was no significant difference in all variables, except for PaO2/FiO2 and HCO3- (mmol/L), between the two groups (P > 0.05). Additionally, factors such as renal dialysis, chronic respiratory disease, and leukemia/myeloma were associated with patient mortality (P < 0.05). The APACHE III score was also associated with mortality (P = 0.001). Conclusions: Given the differences in clinical indicators between patients with PD and the control group, it is suggested that these differences be considered in providing clinical care to these patients.